BASIC CELL STRUCTURE AND FUNCTION --PPDS

tentang sel

1. KULIAH BIOLOGI MOLEKULER PROGRAM PENDIDIKAN DOKTER SPESIALIS (PPDS-1) FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA PJMK: Prof . Dr. dr. Ketut Suwiyoga , SpOG (K ) Dosen Pengajar : Dr. dr. Desak Made Wihandani , M.Kes Dr. rer . nat. dr. Ni Nyoman Ayu Dewi , M.Si

2. Topics Cell structure and function Genome organization Signal Transduction DNA and RNA structure Replication Mutation DNA repair Transcription Translation Control of Gene Expression Molecular Biology Technique Application of Molecular Biology in Medicine Genetic Variation Genotyping

3. Ni Nyoman Ayu Dewi Dept. of Biochemistry Faculty of Medicine and Health Sciences Udayana University

4. http:// www.encognitive.com

5. Characteristic Prokaryotic Eukaryotic

6. http://www.mhhe.com http://facinatingamazinganimals.wordpress.com

7. www.stiffneck.org

8. DNA RNA PROTEIN DNA REPLICATION TRANSCRIPTION REVERSE TRANSCRIPTION TRANSLATION RNA REPLICATION

9. www.tokresource.org

10. http://hyperphysics.phy-astr.gsu.edu http://ridge.icu.ac.jp/biobk/BioBookCELL2.html

11. Can be found in both prokaryotes and eukaryotes Eukaryotic ribosomes are slightly larger than prokaryotic ones Structurally consist of a small and larger subunit Biochemically consist of  ribosomal RNA  ( rRNA ) and some 50 structural proteins Free ribosomes or as a cluster on the  endoplasmic reticulum Catalyze the synthesis of protein

12. http://micro.magnet.fsu.edu

13. Smooth and rough ER Forms the outer bilayer of the nuclear envelope Protein processing and lipid biosynthesis Regulate the cytoplasmic Ca 2+ concentration Very dynamic; continuous bidirectional traffic between ER and Golgi apparatus

14. http://jc-biology.blogspot.com/2011/02/structure-and-functions-of-organelles.html

15. http://bass.bio.uci.edu

16. http://www.fastbleep.com

17. http://micro.magnet.fsu.edu/cells/lysosomes/lysosomes.html

18. Primary role: to produce 90% energy (ATP) via oxidative phosphorylation. M itochondrial dysfunction  defect on oxidative phosphorylation, usually coincides with the occurrence of excess Reactive Oxygen Species (ROS) production  oxidative stress

19. http://bioserv.fiu.edu http://www.biology4kids.com/files/cell_lysosome.html

20. http://micro.magnet.fsu.edu/cells/peroxisomes/peroxisomes.html

21. Characteristics of lysosomes: fuses with food vacuoles and membranous vesicles contains hydrolytic enzymes for digestion digests macromolecules breaks down damaged organelles built with proteins from the rough ER Characteristics of peroxisomes: not a part of the endomembrane system break down substances via oxidation detoxify break down fatty acids built with proteins from ribosomes in the cytosol Campbell, Neil and Jane Reece, Lisa Urry et al.  Biology , 8th ed. Pearson Education. 2008.

22. Microfilaments solid protein (actin) which is assembled at one end and disassembled at the other end maintain cell shape by resisting tension (pull) used in cell division muscle contraction Intermediate filaments - rope-like fibrous proteins provide structural reinforcement by resisting tension (pull) anchor organelles keep nucleus in place Microtubules - hollow tubes of tubulin (a globular protein) maintains cell shape by resisting compression (push) anchor organelles movement of organelles track for motor proteins http://www.uic.edu

23. http://id.images.search.yahoo.com/images/view