Betamethasone drug profile

Betamethasone drug profile

1. Betamethasone Norah fahad alfayez

2. Objectives *Drug Name. *Route of administrations. *Doses. *Classifications. *Mechanism of actions. *indications. *Pharmacokinetics. *Side and adverse effect. *dosage form. * Contraindications . * Special Considerations .

3. Drug Name *chemical: 9-Fluoro-16beta-methylprednisolone . *Genric name: Betamethasone .

4. Brand Name Routes of administrations Doses

5. classifications * Antifungal agent, topical corticosteroid+systamic.

6. * Betamethasone is a glucocorticoid receptor agonist. This leads to control the rate of protein synthesis,depresses the magration of polymorphonu-clear leukocytes, fibroblasts; reverses capillary peme-abillity and lysosomal stabilization at the cellular level to prevent or control inflammation. Clotrimazole is antifungal agent that bind to phosphlipids in the fungal cell membrane altering cell wall permeabillity resulting in loss of essential intracellular elements, and it becomes active when it is not bound to transcortin. Mechanism of action

7. Indications *Topical use (cream, lotion and ointment):  for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, such as allergic reactions, eczema, and psoriasis *Topical use (foam):  relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp *Systemic use:  for the treatment of edocrine disorders, rheumatic disorders, collagen diseases, dermatological diseases, allergic states, ophthalmic diseases.

8. Pharmacokinetic *Administratiom: taking with food (oral) *half-life: 6.5 hours. *protein binding: 64% *Distribution:  Distributed throughout body tissues; crosses the placenta and enters the breast milk. *Metabolism:  Hepatic(cyp3A4) *Excretion:  Via urine (<5% as unchanged drug). *renal clearance: 9.5mL\min

9. Side and adverse effect *Topical: Skin irritation, redness, rash, itching , or allergic inflammation of the skin. Spread or worsening of untreated infections. Thinning of the skin. Reduced skin pigmentation. telangiectasia. Hypertrichosis. *oral and IM: Abdominal pain and Muscles weakness. insomnia,behavioural changes. Blurred vision. Dizziness, headache and seizures.

10. Contraindications 8-Contraindications: * Hypersensititivity to betameth-sone,clotrimazole,other corticosteroids. *Untreated serious infections.

11. Special Considerations *Pregnancy: Category: C *Lactation : systemically administered corticosteroids enter breast milk and could suppress growth.   * pediatrics: Use lowest dose (Not recommended for children under 17).

12. Dosage Form *Topical:base Cream as valerate: Generic: 0.1% (15 g, 45 g) . Gel as dipropionate augmented :Generic: 0.05% (15 g, 50 g). Lotion as dipropionat : 0.05% (60 mL). Ointment as dipropionate: 0.05% (15 g, 45 g). *systamic: Solution, Oral: Celestone: 0.6 mg/5 mL Suspension, Injection: Celestone Soluspan: Betamethasone sodium phosphate 3 mg and betamethasone acetate 3 mg per 1 mL (5 mL) [contains benzalkonium chloride, edetate disodium].

13. References : * Saudi national formulary book *Lixy application. * http://reference.medscape.com/ * http://www.webmd.com/ * http://www.Uptodate.com/

14. Thank you Any questions?