Bio 350- Ch 4 (1).pptx Molecular Biology

Chapter 4 Protein Structure and Function

1. Ch. 4 Protein Structure and Function 1

2. Protein Folding 11

3. Denaturing & Renaturation 12 Other Factors?

4. Misfolded Proteins Neurodegenerative Disorders Alzheimer’s Huntington’s Prion diseases BSE in cattle Scrapie in Sheep Creutzfeldt-Jakob 13

5. Chaperone Proteins 14

6. Proteins come in a wide variety of complicated shapes 15

7. α helix & β-pleated sheet 16

8. 4 Levels of Protein Structure 17

9. Extracellular Proteins are Often Stabilized by Covalent-Cross Linkages Disulfide bonds S-S Join 2 aa or 2 peptides Act as a molecular staple 18

10. How Proteins Work Binding Specificity Strength varies Ligand & Binding sites 19

11. Ligand Binding 20

12. Billions of Different Antibodies- Bind Antigen 21

13. Enzymes are Powerful & Highly Specific Catalysts 22

14. 23

15. Lysozyme Illustrates How an Enzyme Works Enzyme Substrate Enzyme-substrate complex Enzyme-product complex Product 24