Biosynthesis of aspartate

biosynthesis of aspartate

1. PRESENTATION ON BIOSYNTHESIS ASPARTATE AMINO ACID GOVERNMENT PHARMACY COLLEGE SAJONG RUMTEK

2. SUBMITTED BY 5TH SEMESTER STUDENTS SACHIN KUMAR PRASAD SARASWATI SHARMA ABISHEK BHATTRAI PREM DORJEE TAMANG BABITA PRADHAN DEEKU CHETTRI PRIYA KUMARI PINKI KUMARI DINESH REGMI AVAY PRADHAN

3. CONTENTS 1 Introduction 02 Types of aspartic acid 3 Biosynthesis 4 Functions of aspartic acid 05 Uses and Health benefits

4. What is amino acid? Amino acid, any of a group of organic molecules that consist of a basic amino group (―NH2), an acidic carboxyl group (―COOH), and an organic R group (or side chain) that is unique to each amino acid. The term amino acid is short for α-amino [alpha-amino] carboxylic acid. Each molecule contains a central carbon (C) atom, called the α-carbon, to which both an amino and a carboxyl group are attached. The remaining two bonds of the α-carbon atom are generally satisfied by a hydrogen (H) atom and the R group. The formula of a general amino acid is: The amino acids differ from each other in the particular chemical structure of the R group.

5. Nonessential means that our bodies produce an amino acid, even if we do not get it from the food we eat. Nonessential amino acids include: alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, proline, serine, and tyrosine NON-ESSENTIAL Essential amino acids cannot be made by the body. As a result, they must come from food.The 9 essential amino acids are: histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine T YPES OF AMINO ACID ESSENTIAL

6. This is non essential and glucogenic amino acid. Aspartate is also known as aspartic acid. In 1868, aspartic acid was isolated from legume in plant seeds and is apparently known as an amino acid obtained as a product of the hydrolysis of protein . INTRODUCTION Chemical formula C 4 H 7 NO 4 Molar mass 133.103  g·mol −1 Appearance colourless crystals Density 1.7 g/cm 3 Melting point 270 °C (518 °F; 543 K) Boiling point 324 °C (615 °F; 597 K) (decomposes) Solubility in water 4.5 g/L

7. I t contains an amino group and a carboxylic acid. Its α-amino group is in the protonated –NH + 3  form and its α-carboxylic acid group is deprotonated −COO −  . Chemical formula of aspartic acid is C 4 H 7 NO 4 STRUCTURE

8. L-ASPARTIC ACID TYPES OF ASPARTIC ACID D-ASPARTIC ACID

9. — D-ASPARTIC ACID D- aspartic acid is used in body functions but not necessarily in the making of the body proteins. It is commonly used to reduce the feelings of tiredness, to boost the athletic capabilities or to increase the size and strength of the body muscles. It can affect the level of testosterone in a male body playing a larger role in the development of male reproductive tissues.

10. L-ASPARTIC ACID L-aspartic acid is the L- enantiomer of aspartic acid. It has a role as an E.coli metabolite, a mouse metabolite and a neurotransmitter. L- aspartic acid has been found throughout all human tissues, and has also detected in most biofluid, including blood, breastmilk, saliva, and sweat. Within the cell, L-aspartic acid is primarily located in the cytoplasm and mitochondria. It exists in all eukaryotes, ranging from yeast to human. L- aspartic acid participates in a number of enzymatic reaction

11. VEGETABLE SOURCES DIETARY SOURCES OF ASPARTIC ACID OAT FLAKES AVOCADO

12. MOLASSES SUGAR BEETS

13. ANIMAL SOURCES SAUSAGE MEAT OYSTERS

14. BIOSYNTHESIS OF ASPARTATE In the human body aspartate is most frequently synthesis though the transamination of oxaloacetate. The biosynthesis of aspartate is facilitated by an aminotransferase enzyme. The transfer of an amine group from another molecule such as alanine or glutamine yield aspartate and an alpha-keto acid.

15. FUNCTION OF ASPARTIC ACID In the urea cycle , aspartate reacts with citruillin to form arginosuccinate, which is cleaved , forming an essential amino acid arginine and fumarate. Aspartate reacts with inosine monophosphate(IMP) to form adenosine monophosphate (AMP). This amino acid is necessary for stamina brain and neural health.

16. USES It is used to reduce feelings of tir.edness Improve athletic performance. Increase the size and strength of muscles It is also used to treat depression and fatigue Aspartates are taken orally to reduce fatigue, and enhance athletic performance Mineral aspartates have also resulted in blood pressure lowering effects and enhanced wound healing.

17. 3 1 2 4 Female fertility Increase testosterone levels Promote sperm quality HEALTH BENEFITS Enhance memory

18. REFRENCE https://www.planetayurveda.com/library/aspartic-acid https://en.m.wikipedia.org/wiki/Aspartic_acid#:~:text=Sources-,Dietary%20sources,meats%2C%20sausage%20meat%2C%20wild%20game https://www.vedantu.com/chemistry/aspartic-acid https://www.slideshare.net/mobile/mprasadnaidu/biosynthesis-of-amino-acids

19. THANK YOU!