BRONCHODILATORS -SALBUTAMOL AND TERBUTALINE

BRONCHODILATORS -SALBUTAMOL AND TERBUTALINE , BPHARM 3RD YEAR PHARMACOLGY 3

1. GITANJALI COLLEGE OF PHARMACY NAME: MD KAIF ALI UNIVERSITY ROLL: 36201921011 REG. NO: 213620201910015 OF 2021 SUBJECT: PHARMACOLGY III ( PT-618) B.PHARM 3 RD YEAR 6 TH SEM SESSION: 2021 - 25 INTERNAL ASSESSMENT (CA-1)

2. TITLE-BRONCHODILATORS : SALBUTAMOL & TERBUTALINE CONTENTS Bronchodilators Classification Of Bronchodilators β 2 Sympathomimetics ( Salbutamol & Terbutaline ) Mechanism Of Action Drug-Drug Interaction Uses & Adverse Effect

3. BRONCHODILATORS What is Bronchodilators? These are those drugs which are basically open the airways of lungs to make breather easier. A doctor may prescribe them for asthma and other respiratory conditions .

4. Classification of Bronchodilators Fig. 1.1.  Classification of Bronchodilators

5. β 2 SYMPATHOMIMETICS Those drugs which copy the action of β 2 receptor antagonist. This drugs given their action why stimulating the sympatommetic system through  β  2 receptor. Salbutamol ( Albuterol ) - A highway selective β 2 agonist. It is short acting beta to agonist (SABA) which has a repeat on set of acction (within 5 minutes) and provide relief for 2-4 hours. It is used to abort and terminate attacks of asthma. Dose - 2-4 mg oral,8mg SR tab.,2mg/5ml syrup,100-200 μ g by inhalation. Terbutaline – It is similar to salbutamol in properties and use.

6. MOA OF SALBUTAMOL AND TERBUTALINE Activation of β -2 adrenergic receptors Activation of adenyl cyclase Increased intracellular concentration of cyclic- 3',5'-adenosine monophosphate (cyclic AMP) Activation of protein kinase A Inhibits phosphorylation of myosin Decreased intracellular ionic calcium concentrations Relaxation of bronchial smooth musle Salbutamol and Terbutaline

7. DRUG-DRUG INTERACTION The therapeutic efficacy of Salbutamol can be decreased when used in combination with Acebutolol . The risk or severity of hypertension can be increased when Salbutamol is combined with Aceclofenac . The risk or severity of hypertension can be increased when Salbutamol is combined with Acemetacin . Large doses of IV albuterol (not commercially available in the U.S.) and terbutaline sulfate have been reported to cause exacerbation of preexisting diabetes mellitus and ketoacidosis . Salbutamol caused significantly faster elimination of digoxin from the central volume of distribution to deeper compartments .

8. USES OF SALBUTAMOL & TERBUTALINE Asthma Chronic Obstructive Pulmonary Disease(COPD) Coughing Wheezing Bronchitis ADVERSE EFFECT Trembling Nervous Tension Headaches Decrease Urine Convulsions Dry mouth

9. REFERENCES K. D. Tripathi , “Essentials of Medical Pharmacology,” 8th Edition, Jaypee Brothers Medical Publishers (P) LTD, New Delhi, 2003. Page No – ( 240-243 ) Shanbhag “Pharmacology for Medical Graduates”, 4th Edition 2020 by Smita Shenoy , Tara V Shanbhag .Page No – (256-258)