Brugia species

educational material

1. Brugia species Mosab Nouraldein

2. They cause lymphatic filariasis They are 2 species B.malayi and B.timori

3. History Steffen Burg discover B.malayi in Malaya( S outheast Asia),1927 Brugia timori was firstly described in 1965 in Timor .

4. Life cycle Indirect life cycle Definitive host : human Intermediate host : mosquitoes of the genus Mansonia , Aedes and Anopheles

5. Symptoms Lymphadenitis: swelling of the lymph nodes Lymphangitis: inflammation of the lymphatic vessels in response to infection

6. Lymphedema ( elephantiasis): The most obvious sign of infection, elephantiasis, is the enlargement of the limbs–usually the legs. A late complication of infection, elephantiasis is a form of lymphedema and is caused by repeated inflammation of the lymphatic vessels .

7. Diagnosis Examination of thick blood smear Serological test (e.g. ELISA). PCR Microfilariae can be detected in urine in case of chyluria

8. control Early diagnosis Early treatment to the patients Vector control Health education