C H N S ANALYSIS.pptx

CHNS Analysis .
advanced pharmaceutical analysis.
determination of elemental impurities.
rapid determination of carbon, hydrogen ,nitrogen and sulfur in organic matrices and other type of materials.

1. C H N S ANALYSIS SUBMITTED BY: ANUPAMA.C.P 1 SEM M-PHARM

2. INTRODUCTION CHNS elemental analysers provide a mean for the rapid determination of carbon, hydrogen, nitrogen, and sulphur in organic matrices and other type of materials. They are capable of handling a wide variety of sample types including solids, liquids, volatile and viscous samples in the fields of pharmaceuticals, polymers etc.

3. PRINCIPLE In combustion process ( furnace at 1000°c) Carbon is converted into carbon dioxide Hydrogen to water Nitrogen to nitrogen gas / oxides of nitrogen Sulphur to sulphur dioxide If other element such as chlorine is present , they converted into combusion products, such as hydrogen chloride. Combusion prdts are swept out from the chamber using inert gas (helium) and passed over heated high purity copper.

4. The gases then passed through adsorbent trapes to leave only Co 2, H 2 O, N 2 ,SO 2. Determination can be carried out in a variety of ways GC separation followed by qualification using thermal conductivity detection. A partial separation by GC followed by thermal conductivity. A series of infra red and thermal conductivity.

5. INSRUMENTATION

6. Combustion elemental analysis are manufactured in a variety of configurations to suit specific application, element of interest, sample type and size etc. All instruments require two gas supplies: An inert carrier gas (helium recommended) High purity oxygen ( minimum 99.9995%) Strict specification for oxygen is associated with the need to reduce the nitrogen “blank” contribution. Additionally, GC type gas filters are also usually fitted to prevent trace organic species and water entering the combusion .

7. The choice of sample introduction system will depend on the application and sample type For solids or viscous liquids, samples are weighed out into tin capsules. For liquids, samples can be sealed in individual vials or introduced via a liquid auto sampler. Both capsules and vials are pre-cleaned and dried to avoid trace contamination from water and oils.

8. Instruments are classified as ‘static’ or ‘dynamic’ in terms of their combustion characteristics. In the static type a pre-set volume of oxygen is added to the combusion tube before the sample is introduced. In the dynamic type ,the oxygen is added to the tube at the same time as the sample introduction and continuous to flow for a set time.

9. APPLICATIONS In analytical laboratories for over thirty years. Used in pharmaceuticals, chemicals, oil-related products, catalysts and foods. In oil industry, regular monitoring of coke build up on refinery catalyst to ensure that regeneration procedures. In food analysis, the determination of nitrogen is important for pricing grain and evaluating meat products.

10. REFERENCES www. Slideshare . net Elemental impurities- chns analysis