Calcium channel blockers

Calcium Channel blockers

1. Dr. Kumbhare Manoj R. Professor S.M.B.T . College of Pharmacy Dhamangaon Nashik (M.S .). Calcium channel blockers

2. After successful completion of topic, a learner should be able to- Understand History of Calcium channel blockers Know examples of Calcium channel blockers Explain applications of Calcium channel blockers Mechanism of action of Calcium channel blockers Learning Outcome 2

3. Introduction History of Calcium channel blockers Know examples of Calcium channel blockers Explain applications of Calcium channel blockers Mechanism of action of Calcium channel blockers Content 3

4. Calcium channel blockers were first identified in the lab of German pharmacologist Albrecht Fleckenstein beginning in 1964. In 1025, Avicenna introduced the medicinal use of Taxus baccata for phytotherapy in The Canon of Medicine . He named this herbal drug " Zarnab " and used it as a cardiac remedy. This was the first known use of a calcium channel blocker drug, which were not in wide use in the Western world until the 1960s. Introduction 4

5. Calcium channel blockers ( CCB ), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium (Ca 2+ ) through calcium channels 5

6. Mechanism In the body's tissues, the concentration of calcium ions (Ca 2+ ) outside cells is normally about 10000-fold higher than the concentration inside cells. Embedded in the membrane of some cells are calcium channels. When these cells receive a certain signal, the channels open, letting calcium rush into the cell. The resulting increase in intracellular calcium has different effects in different types of cells. Calcium channel blockers prevent or reduce the opening of these channels and thereby reduce these effects. 6

7. Classes 1.1 Dihydropyridine 1.2 Non- dihydropyridine 1.2.1 Phenylalkylamine 1.2.2 Benzothiazepine 1.2.3 Nonselective 1.2.4 Others 7

8. Dihydropyridine (DHP) Dihydropyridine (DHP) calcium channel blockers are derived from the molecule dihydropyridine and often used to reduce systemic vascular resistance and arterial pressure. Manidipine Nicardipine , Nifedipine , Nilvadipine , Nimodipine This substance can pass the blood-brain barrier and is used to prevent cerebral vasospasm . 8

9. This CCB class is easily identified by the suffix "- dipine ". Amlodipine 9

10. Nifedipine 10

11. 1.2 Non- dihydropyridine 1.2.1 Phenylalkylamine Verapamil 11

12. Summary Introduction Mechanism of action Examples Applications 12

13. 13