Calcium Gluconate

Muhammad Adeel
Pharmacist
G.C University Faisalabad

1. Calcium Gluconate

2. Contents Introduction Synonyms Formula Properties Preparation Pharmacological Properties Therapeutic Applications Side Effects Drug Interactions Contraindications

3. Introduction of Calcium Gluconate Anhydrous Compound Mineral Supplement Essential Body Electrolyte Muscle and Nerve Integrity Also Essential for Muscle Contraction Cardiac Functions Coagulation of the Blood

4. Synonyms of Calcium Gluconate Calcium D-gluconate Calcium salt of Gluconic acid Gluconic Acid hemi-calcium salt

5. Formula of Calcium Gluconate Chemical Formula = C 12 H 22 CaO 14 Structural Formula =

6. Properties of Calcium Gluconate Solubility = Slowly in H 2 O, Insoluble in organic solvent and alcohol. Natue = Inorganic and Mildly acidic Appearnce = Powder and granules. Odour = Odorless

7. Preparation of Calcium Gluconate Oxidation of Glucose to Gluconic acid In the presence of calcium..

8. Pharmacological Properties of Calcium Glucoante Plays role in physiology of organism and cell. Pivotal role in signal transduction pathway. Acts as 2 nd messenger in neurotransmitter release of neurons and contraction of all muscle cell types. Many enzymes require calcium ions as a cofactor. Notable example is blood clotting cascade.

9. Pharmacological Properties of Calcium Gluconate Extracellular calcium is important for maintaining potential difference across excitable cell membranes as well as bone formation. Calcium is absorbed from the small intestine by active transport and passive diffusion. It crosses placenta and enters in breast milk.

10. Therapeutic Applications of Calcium Gluconate Hypocalcemia: Related to Hypothyroidism. Magnesium Sulphate Overdose: Hydrofluoric acid Burns: Calcium gluconate reacts with hydrofluoric acid to form insoluble, nontoxic calcium fluoride.

11. Therapeutic Applications of Calcium Gluconate Hyperkalemia: Black Widow spider bites: As an anti-dot Muscle Cramping:

12. Side Effects of Calcium Gluconate Nausea, Constipation, Stomach upset Rapid I.V may cause hypercalcemia which can result in vasodilation, cardiac arrhythmias, decreased Blood Pressure and bradycardia. I.M may lead to local necrosis and abscess formation.

13. Drug Interactions of Calcium Gluconate Digoxin Antacids or other calcium supplements. Vitamin-D supplement. Doxycycline. Tetracycline.

14. Contraindications of Calcium Gluconate Hypercalcemia Ventricular Fibrillation. Kidney Problem