Calotropis.pptx

calotropis toxicology

1. CALOTROPIS GIGANTEA

2. Types Calotropis gigantea ( akdo , madar ) has purple flowers Calotropis procera has white flowers

3. C. gigantea c.procera (not scented) (scented)

4. Active principles When the leaves and stem when incised yield thick acrid, milky juice which also has Trypsin. Calotropin (glycoside) Calotoxin Calactin Uscharin Gigantin

5. Signs and Symptoms Applied to the skin - it causes redness and vesication. When taken by mouth- the juice produces an acrid bitter taste burning pain in throat and stomach Salivation ,stomatitis, vomiting, diarrhoea dilated pupils tetanic convulsions collapse and death.

6. Fatal Dose: Uncertain. Fatal Period: 6 to 12 hours.

7. Treatment Stomach wash Demulcents (mineral oil) Glucose saline IV Symptomatic management

8. Postmortem Findings Dilated pupils Froth at the nostrils Stomatitis Inflammation of gastrointestinal tract + Necrosis of mucosa The abdominal viscera and brain are congested.

9. MEDICO- LEGAL IMPORTANCE The flowers, leaves, root and juice are used in Indian medicine. The juice is taken by mouth or introduced into uterus on an abortion stick for criminal abortion. It is sometimes used for infanticide and rarely for suicide or homicide Juice is used as a vesicant, depilatory and for chronic skin infection.

10. MEDICO- LEGAL IMPORTANCE To produce artificial bruise. As a cattle poison, it is smeared on a cloth and pushed into the rectum of the animal, or is given with fodder. It is sometimes used as arrow poison. The root of calotropis procera is highly poisonous to cobras, and other poisonous snakes, which cannot stand its smell.

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