Cannabis Use Disorder for students..pptx

one of the Good PPt for Medical and Nursing Students. Very helpful for academics.

1. Cannabis Use Disorder Dr. Prakashkumar More.

2. Anti Craving Drugs N -acetylcysteine (NAC) Several promising studies with adolescents have also been conducted with  N -acetylcysteine (NAC), an anti-inflammatory supplemental amino acid that is hepato-protective and a glutamate modulator in the central nervous system. In the first published, fully powered clinical trial with positive results for pharmacotherapy for cannabis use disorder, Gray and colleagues initially found that youths and young adults (ages 15–21, N=116) dosed with 1,200 mg NAC twice a day along with contingency management had 2.4 times the odds of cannabis-negative urines as those assigned to placebo medication with contingency management. However, a follow-up study did not replicate their initial results among adult participants. 

3. Other Drugs Most specific to the primary treatment of cannabis use disorder are medications that are active at the cannabinoid subtype 1 (CB-1) receptor, disproportionately found throughout the central nervous system. Dronabinol , a Schedule III synthetic THC for the treatment of nausea and cachexia, partially agonizes CB-1 receptors. In addition, a newer analogue of THC, nabilone (Schedule II), has even stronger activity at the CB-1 receptor, potentially making it more reinforcing for patients through positive feel-good effects. Although dronabinol has demonstrated superior control of withdrawal symptoms in prospective randomized controlled trials and a few case studies, it has often fallen short of being associated with reductions in cannabis use. Further research on nabilone is needed, but it remains a promising candidate that could be helpful for individual patients. A recent small pilot study demonstrated the safety and feasibility of nabilone as pharmacotherapy for cannabis use disorder. New compounds such as second-generation cannabinoid receptor antagonists and other related inhibitors, such as CBD, a cannabinoid that acts as a negative allosteric modulator, are also being explored as potential candidates .