Case study of liver function test , different liver functiontest with its normal limits , clinical significance

Case study of liver function test
Different liver function test
Normal range of liver function tests
Clinical significance of liver function tests
History of patient
Case study of liver patient
Liver Cirrhosis

1. CASE STUDY OF LIVER FUNCTION TESTS

2. Normal Ranges of LFT and Interpretation

3. Case Study Of Patient Name : Rabin Shrestha Age : 58 years/ male LIVER FUNCTION TESTS TESTS Patients value Normal ranges Total bilirubin : 3.14 0.1-1.2 mg/dl Direct bilirubin : 2.20 0.1-0.3 mg/dl SGPT / ALT : 97 7- 50 IU/L SGOT / AST : 290 10-40 IU/L Albumin : 3.9 3.4- 5.4 mg/dl GGT : 647 10-87 IU/L

4. Interpretation of liver function tests Types of bilirubin : Direct bilirubin also known as Conjugated bilirubin. Indirect bilirubin also known as Unconjugated bilirubin. Patient report indicates increased Level of both Conjugated and Unconjugated bilirubin.

5. AST and ALT levels These are the enzymes indicating hepatocellular damage. The levels of ALT in serum are elevated in all liver diseases . Very high levels (more than 1000 units) are seen in acute hepatitis (viral&toxic) Elevation of ALT is more in cases of hepatic disease in compare to AST. But AST may be more than ALT in alcoholics liver disease. In patient report we can observe AST level is almost 7 times higher than then Upper limit of normal range and ALT level is almost 2 times increased than Upper limit of normal range . These value indicates that the patient may be suffering from alcoholics Liver diseases.

6. Gamma Glutamyl Transferase (GGT) GGT is clinically important because of its sensitivity to detect alcohol abuse . Elevated levels of GGT are observed in chronic alcoholism , pancreatic disease , Myocardial infraction , renal failure, chronic obstructive pulmonary disease. In patient report we can observe the elevated levels of GGT 8 times increased from Upper limits . So, we can interpret that the patient may be alcoholics .

7. Alkaline Phosphatase (ALP) Very high levels of ALP are noticed in patients with cholestasis or hepatic or Hepatic carcinoma. In parenchyma diseases of liver, mild Elevation of ALP is noticed . Very high levels of ALP (10-12 times of upper limit may be noticed in extra hepatic obstruction caused by gall stones . High levels of ALP (10- 25 times of Upper limit ) are seen in bone disease where osteoblastic activity is enhanced . In patients report ALP is within normal range .

8. Conclusion : In this case we can interpret that the patient may be alcoholics so, he is suffering from alcoholic liver disease . Mechanism of alcoholics liver diseases :

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