Centrosome and centrioles

The centrosome is the microtubule organising centre (MTOC) of eukaryotic cells.

1. CENTROSOME & CENTRIOLES Presented by :- SAKEEL AHMED NIPERA1820PC01 Dept. of Pharmacology and Toxicology . NIPER Ahmedabad 1

2. INTRODUCTION The centrosome is the microtubule organising centre (MTOC) of eukaryotic cells. The centrosome was discovered by Edouard Von Beneden in 1883 and later described and named in 1888 by theodor boveri . Centrosome composed of two centrioles arranged at right angle to each other and surrouded by an amorphous mass of protein called pericentriolar material (PCM). 2

3. Each centriole of the centrosome is based on a nine triplet microtubule assembled in cartwheel structure and contain Centrin (Duplication) Nexin Tektin ( cilia & flagella) A triplet contains one complete and two incomplete microtubules. STRUCTURE 3

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5. FUNCTIONS Mitotic spindle formation during mitosis. Mother centriole makes cilia and flagella. Organise the Microtubules. Cell division :- Centrosome replicates during the S phase of the cell cycle. During mitosis centrosome migrates to opposites poles of the cell. Mitosis spindle then form between the two centrosomes . 5

6. Centrosome cycle Centrosome duplication :- G1 and S phase Centrosome maturation :- G2 phase Centrosome sepration :- Mitosis phase Centrosome disorientation :- late mitosis phase 6

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8. References Kumar Pranav , Life sciences fundamental and practice 1 , 6 th edition 2018 , published by Pathfinder Publication New Delhi . Paul T. Conduit and others , centrosome function and assembly in animal cells, published by Nature Reviews (Molecular cell biology) , 2015. 8

9. THANK YOU 9