CHANNEL PROTEIN Presented by Najwa Adel Abd- Elsamad Naglaa Ashraf Abd- Eldayem Hager Abd- Elnasser Deraya University | 2024
A channel protein is a special arrangement of amino acids which embeds in the cell membrane, providing a hydrophilic passageway for water and small, polar ions. Like all transport proteins, each channel protein has a size and shape which excludes all but the most specific molecules. A generic channel protein is seen below, embedded within the membrane. Ions, the small green hexagons, travel through the channel protein. They move from an area of high concentration to an area with a lower concentration. INTRODUCTION
TYPES OF CHANNEL PROTEIN A non-gated channel protein is a protein that remains open all the time, allowing ions and water to flow through the cell membrane. It's needed for maintaining water and ion balance, but often has disadvantages. The second type addresses this issue. Non-Gated Gated channel proteins are crucial for cellular functions, allowing electrical energy to build up inside cells. They react to ion channel signals, allowing ions to flow through the membrane, causing rapid signal transmission through the body. Gated
Function: Channel proteins, either gated or non-gated, play different roles in cell function. Non-gated channels allow ions and water to flow freely, while gated proteins maintain ion gradients. Closed channels act as corked bottles, limiting ion movement. Cells use these proteins for water balance and charge building. Structure: Channel proteins consist of identical subunits forming a hydrophilic region. Gated channels change conformation upon signal reception, allowing access to the hydrophilic passageway. Non-gated channels form circles with non-polar amino acids, anchoring the protein within the hydrophobic cell membrane. STRUCTURE & FUNCTION