Charcot

Medicine PG poster presentation

1. CHARCOT’S – INTERESTING FACTS
1. CHARCOT-MARIE-TOOTH DISEASE ( CMT )
ALSO KNOWN AS HEREDITARY MOTOR AND SENSORY NEUROPATHY (HMSN) OR PERONEAL
MUSCULAR ATROPHY .
·HETEROGENEOUS INHERITED DISORDER OF NERVES (NEUROPATHY ) THAT IS CHARACTERIZED BY
LOSS OF MUSCLE TISSUE AND TOUCH SENSATION, PREDOMINANTLY IN THE FEET AND LEGS BUT
ALSO IN THE HANDS AND ARM
2. CHARCOT’S JOINT/FOOT ( NEUROPATHIC OSTEOARTHROPATHY )
·REFERS TO PROGRESSIVE DEGENERATION OF A WEIGHT BEARING JOINT, A PROCESS MARKED BY BONY
DESTRUCTION, BONE RESORPTION , AND EVENTUAL DEFORMITY.
·IF THIS PATHOLOGICAL PROCESS CONTINUES UNCHECKED, IT COULD RESULT IN JOINT
DEFORMITY, ULCERATION AND SUPERINFECTION,
3. CHARCOT'S NEUROLOGIC TRIAD
· NYSTAGMUS
·INTENTION TREMOR
·SCANNING OR STACCATO SPEECH .
·THIS TRIAD IS ASSOCIATED WITH MULTIPLE SCLEROSIS , WHERE IT WAS FIRST DESCRIBED
4. CHARCOT'S CHOLANGITIS TRIAD
· JAUNDICE
·FEVER USUALLY WITH RIGORS
· RIGHT UPPER QUADRANT ABDOMINAL PAIN .
WHEN THE PRESENTATION ALSO INCLUDES HYPOTENSION AND MENTAL STATUS CHANGES , IT IS KNOWN AS
REYNOLDS' PENTAD
5. CHARCOT-BOUCHARD ANEURYSMS ( MILIARY ANEURYSMS OR MICROANEURYSMS)
· ANEURYSMS OF THE BRAIN VASCULATURE WHICH OCCUR IN SMALL BLOOD VESSELS (LESS THAN 300 MICROMETRE
DIAMETER). . CHARCOT-BOUCHARD ANEURYSMS ARE MOST OFTEN LOCATED IN THE BRAINSTEM.
·ASSOCIATED WITH CHRONIC HYPERTENSION
6. CHARCOT-LEYDEN CRYSTALS
· MICROSCOPIC CRYSTALS
·
·ALLERGIC DISEASES SUCH AS ASTHMA OR PARASITIC INFECTIONS