CHEM F311 Lecture 31 stereoselective reactions 28 Oct 2024.pptx

Notes

1. CHEM F311 Organic Chemistry – III Lecture 31 – 28 th Oct. 2024

2. Recap Stereospecific reactions Preview Stereoselective reactions Conformational control in Stereoselective reactions One group C-C disconnections: Carbonyl compounds

3. Stereochemical synthesis of multistriatin

4. Key transformation in synthesis of multistriatin A (±)A A A

5. Stereoselective reactions LiAlH (O- t -Bu) 3 i -PrOH with ( i -PrO ) 3 Al base ???? base ????

6. Conformational control in stereoselective reactions 60 % from cyclohexenone

7. Axial attack to make a chair