Chemical Reactions of Amines.ppt

Chemical reactions of amines are discussed

1. AMINES
By
Dr. Nidhi Gupta
M.M. College of Pharmacy
Mullana, Ambala, India

2. Chemical reactions of amines or Difference between primary,
secondary and tertiary amines

4. 2. Alkylation of amines:
Aprimaryamineistreatedwithanalkylhalideinabasic
mediumsuchasammonia,thehalogenatomofthealkylhalide
isdisplacedyieldingdialkylammoniumsaltwhichinthe
presenceofammoniaatoncegivesasecondaryamine.

5. 3. Acylation of amines:
Primaryandsecondaryaminesreactwithacylhalidesandcarboxylicanhydrides
wherethehydrogenatomattachedtothenitrogenisreplacedbyacylgroup.
PrimaryamineproducesN-substitutedamidewhereassecondaryamineproduces
N,N-disubstitutedamide.
Tertiaryaminedonotreactatall.

6. Schotten-Baumann procedure for acylation of amines
Mechanism for acylation of amines
The reaction takes place by the nucleophillic attack of primary
or secondary amine on to the carbonyl group of the acyl
chloride.

7. 4. Sulphonylation of amines:
Benzenesulphonyl chloride reacts with primary and secondary
amines to form N-alkyl and N, N-dialkyl sulphonamides
respectively.

8. 5. Reactions with Nitrous acid:
Primary amine reacts with nitrous acid to form alcohols.
Secondary amine reacts with nitrous acid to form yellow oily
substances called nitrosoamines.
This reaction is known as Libermann nitrosoamine reaction.
Tertiary amine form the trialkyl ammonium salts of nitrous acid.

15. Structure and uses of Amphetamine
Itbelongstophenylethylamineclassandapotent
CNSstimulantthatisusedinthetreatmentofattentiondeficit
hyperactivitydisorder(ADHD),narcolepsyandobesity.