Chitosan

It is carbohydrate Polymeric System

1. Mr. Sagar Kishor SavaleMr. Sagar Kishor Savale
[Department of Pharmaceutics][Department of Pharmaceutics]
[email protected]@gmail.com
2015-20162015-2016
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2. Chitosan (2-amino-2deoxy-(1 4)- -D-
→ β
glucopyranan), a polyaminosaccharide,
normally obtained by alkaline deacetylation
of chitin is the principal component of living
organisms such as fungi and crustacea.
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3. The degree of N-acetylation (DA) together with
the molecular weight are the most important
parameters for its characterization. The DA,
which is by definition the molar fraction of N-
acetylated units, is a structural parameter
influencing charge density, crystallinity and
solubility, including the propensity to
enzymatic degradation, with higher DAs
leading to faster biodegradation rates
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4. 1) Biocompatibility
2) Nonantigenicity
3) Nontoxicity (Its Degradation Products Are Known
Natural Metabolites)
4) The Ability To Improve Wound Healing/Or Clot
Blood
5) The Ability To Absorb Liquids And To Form
Protective Films And Coatings
6) Selective Binding Of Acidic Liquids, Thereby
Lowering Serum Cholesterol Levels.
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5. It is cationic polyamide
Chitosan reacts chemically with anionic system
It undergoes reactions typical of amines
(For ex. N-acetylation & Schiff reaction)
Acidity-Alkalinity:
PH= 4.0-6.0
Density: 1.35-1.40 g/cm
3
Glass transition temperature: 203
0
c
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6. Moisture content:
- It absorbs moisture from atmosphere
- Particle size distribution: <30 mm
Solubility:
- Sparingly soluble in water
- Practically insoluble in ethanol and other organic solvents
- Solubility is affected by degree of deacetylation

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7. Viscosity:
- The viscosity of chitosan increases with
increasing chitosan concentration, decreasing
temperature, and increasing degree of
deacetylation.
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8. Preparation of microspheres
Taste marked by spray drying
Preliminary study on film dosage form
prepared from chitosan for oral drug delivery
Increased stability of drug
Solubility increases as well as taste masking
Orthopaedic patient
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9. Cosmetic industry
Dental medicine
Enhanced bone formation by transforming
growth factor
Cholesterol lowering effect
Chitosan as a permiation enhancer
Chitosan as mucoadhesive excipient
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10. Aloe Vera Toothpaste
Opthalmic drug delivery
Gene delivery
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11.  Biomedical:
- Drug delivery
- Cell delivery
- Orthopedics
- Wound healing
- Surgical sutures
- Ophthalmology
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12. - Skin treatments
- Pharmaceuticals
- Dentistry
- Bone healing
Nutritional
- Cholesterol-lowering effects
- Fiber and weight loss effects
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13. Cosmetic
- Hair care
- Skin care
- Oral care.
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14. 1)Rarymod C. Rowe, Paul. J.Shesky, and
Sian. C.Owen, Handbook of
pharmaceutical exicipient 5
th
edition, P.no
159-160.
2) http://www.phama info.net
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