Cholecalciferol

VITAMIN D3 IMPORTANCE

1. VITAMIN-D BIOSYNTHESIS - The major natural source of the vitamin D is synthesis of cholecalciferol in the skin from   cholesterol   through a chemical reaction that is dependent on sun exposure  (specifically UVB radiation ). - Cholecalciferol is converted in the liver to Calcidiol (25-hydroxycholecalciferol) -Calcidiol is further hydroxylated by the kidneys to form  calcitriol(also known as1,25-dihydroxycholecalcifero),the biologically active form of vitamin D . - Vitamin D is converted to Calcidiol in the liver . Part of the Calcidiol is converted by the kidneys to calcitriol, the biologically active form of vitamin D. It circulates as a hormone in the blood, regulating the concentration of calcium and phosphate in the bloodstream and promoting the healthy growth and remodeling of bone.

2. REGULATION OF CALCIUM HOMEOSTASIS

3. CALCIUM HOMEOSTASIS PROCESS

4. ROLE OF VITAMIN D IN CALCIUM HOMEOSTASIS

5. ROLE OF VITAMIN D IN CALCIUM HOMEOSTASIS

6. CHOLECALCIFEROL(VITAMIN-D3) COMPOSITION Cholecalciferol chewable tablets 60,000 IU Cholecalciferol 60,000 IU/1gm Sachet INDICATIONS Fractures Osteoporosis DOSE/DOSAGES 1Tab or Sachet per week for 3 Months

7. CHOLECALCIFEROL(VITAMIN-D3) -Helps in maintaining calcium level in blood. -Decreases risk of low BMD . -Enhances calcium absorption from intestine. -Stimulates absorption of phosphate and magnesium ions. -Stimulates differentiation of osteoclasts. -Provide proper balance of calcium and phosphorus in bone to support mineralization. -Facilitates calcium absorption in the kidney.

8. SOURCES OF VITAMIN D

9. AVAILABLE BRANDS IN INDIA BRANDS -CALCIROL(CADILA) -D RISE(USV) -VITOMIN D3(CIPLA) -CALDIKIND(MANKIND) - ROCKBON(ABOTT) -TORFLASH(TORRENT) -GEN D3(MACLEODS) -CALSHINE(ERIS)