Chronic inflammation in Pathology 1 .pptx

pathology

1. Chronic inflammation

2. Resolving and nonresolving inflammation

3. Cell  2010 140, 871-882DOI: (10.1016/j.cell.2010.02.029) Copyright © 2010 Elsevier Inc. Terms and Conditions Factors required to resolve acute Inflammation

4. Cell  2010 140, 871-882DOI: (10.1016/j.cell.2010.02.029) Copyright © 2010 Elsevier Inc. Terms and Conditions Nonresolving Inflammation

5. “Chronic inflammation is a response of prolonged duration (weeks or months) in which inflammation, tissue injury, and attempts at repair coexist, in varying combinations”, Tuberculosis Rheumatoid Arthritis Silicosis Persistent infections Hypersensitivity Toxic agents Chronic inflammation

6. Morphologic Features Infiltration with mononuclear cells, which include macrophages, lymphocytes , and plasma cells; Destruction of parenchyma; R eplacement of damaged tissue with angiogenesis and fibrosis . Acute Chronic Lung

7. Cells and Mediators: Macrophages

8. Macrophages subsets

9. T Lymphocytes

10. Leucocytes Eosinophil Mast cells Neutrophil

11. Granulomatous Inflammation Central necrosis Multinucleate giant cells L ymphocytes Epitheliod cells

12. Morphologic patterns in granulomatous diseases

13. Mechanisms of granulomas formation