Cleft lip & palate topic. I made this topic simple and clear to you

Cleft lip & palate.
I made this topic simple and clear

1. EMBRYOLOGY
CLEFT LIP &
CLEFT PALATE
BY YOGANAND

2. DEVELOPMENT OF LIP
Lower lip is formed by fusion of Mandibular process of both sides
Upper lip is derived from medial nasal and Maxillary processes
Failure of fusion of medial nasal & maxillary process at 5 weeks GA in
one or both sides results in cleft lip

3. *Embryologically, the palate consists of two parts: primary
palate and secondary palate.
*The primary palate develops from the frontonasal process
*Secondary palate develops from the maxillary processes.
*Development of palate begins in the 6th week and
completes by the end of the 12th week. The palate
develops in two stages:
1. Development of primary palate
2. Development of secondary palate.
DEVELOPMENT OF PALATE

4. CLEFT LIP & CLEFT PALATE
1)A cleft lip is a physical split or separation of the two sides of the
upper lip and appears as a narrow opening or gap in the skin of the
upper lip.
2)A cleft palate is a split or opening in the roof of the mouth.

5. INCIDENCE OF CLEFT LIP &
CLEFT PALATE
•About 1 in every 1,600 babies is born with both cleft lip and cleft palate.
•About 1 in every 2,800 babies is born with cleft lip without cleft palate.
•About 1 in every 1,700 babies is born with cleft palate.

6. ETIOLOGY & RISK FACTORS
•Etiology:
•Hereditary
•Family history
•TGFA,TGFB3 &AP2 gene expression
•Teratogens like anti epileptics,anti
Emetics, Dioxin,syphilis,rubella etc
•Associated with downs&wardenburg
syndromes
•Risk factors:
•Smoking
•Anemia
•Diabetes
•Alcohol consumption

9. DIAGNOSIS OF CLEFT LIP AND CLEFT PALATE