Clobazam in febrile seizure prophylaxis

SHORTEST AND PRECISE REVIEW OF LITERATURE ON CLOBAZAM ROLE IN FEBRILE SEIZURES

1. CLOBAZAM in FEBRILE SEIZURE PROPHYLAXIS DR SHAILESH MEHTA MD PEDIATRICS

2. EVIDENCE BASED FACTS Cochrane meta- analysis and ILAE don’t support use of CLOBAZAM in febrile seizures. Cochrane Database of Systematic Reviews 2017, Issue 2. Art. No.: CD003031 . included 40 articles describing 30 randomised trials with 4256 randomised participants RESULT: CLOBAZAM INEFFECTIVE Most studies in favour have sample size 25-70 patients only Indian J Pediatr (2011) 78:38–40 Manreza et al,Arq Neuropsiquiatr 1997;55(4) Rose et al, Indian J Pediatr 2005;72(1)

3. RESCUE VS PROPHYLAXIS RESCUE- IF SEIZURE MORE THAN 15 MIN DIAZEPAMI.V./ RECTAL-0.3- 0.5MG /KG/DOSE MIDAZOLAM INTRANASAL-0.2MG/KG/DOSE CLOBAZAM- NOT USED Cochrane Database of Systematic Reviews 2017, Issue 2. Art. No.: CD003031 Lancet 2005,;366:205-10 PROPHYLAXIS - NO MORE USED- PHENOBARB, VALPARIN DIAZEPAM(ORAL) – 0.3 MG/KG/DOSE 12 HOURLY TILL AFEBRILE FOR 24 HRS CLOBAZAM(ORAL)- 0.5 MG/KG/DOSE- 12HOURLY- FOR 48HRS RANGE 0.3-1MG/KG/DOSE