collagen protein for medical-Biochem 2.0.pptx

This ppt made by BNYS students

1. COLLAGEN PRESENTED BY SADHVI DEVPOORNA MS. ROSHNI NAIKE MS. NANDINI ARORA MS. SUMEDHA GUPTA

2. INTRODUCTION Most common in body. Present in all tissue tendon ligaments Cartilage, Bones. This is ECM. Major structural protein. Highest concentration in skin > cornea.

3. STRUCTURE OF COLLAGEN

4. COLLAGEN SYNTHESIS INTRA CELLULAR EVENTS Fibroblast (endoplasmic reticulum) it is a Preprocollagen . Modification – Hydroxylation. ( vit c) Glycosylation. Triple helix formation .

5. COLLAGEN SYNTHESIS EXTRA CELLULAR EVENTS Pro-collagen Formation, Cleavage of N and C terminal. Lysyl Oxidase (Required Cu) Aldol Condensation. (bond) Tropo collagen Formation

6. TYPES OF COLLAGEN There are 20 type of collagen. Most important are enlisted below: TYPE 1 – Bone, skin, ligament, tendon. TYPE 2 – Cartilage TYPE 3 – Aorta (major blood vessel) TYPE 4 – Basement membrane (in skin, kidney, lungs) TYPE 7 – Anchoring Fibril (BM & Dermal ECM) TYPE 8 – Endothelium (other tissues) TYPE 10 – Hypertrophic cartilage (large space), TYPE 17- Hemi desmosome( ss found in Epidermis), TYPE 19 – Rhabdomyosarcoma cell.

7. FUNCTIONS Imparts strength shape elasticity and support to tissue & organs. To provide alignment of cell for cell anchoring, It can also be elastic as in skin and flexible as in tendons bending around a joint. Proliferation and differentiation of cell. In blood vessel if collagen is exposed, platelet adhere and thrombus formation is initiated. Fill the sclera of eye in collagen form.

8. LIFESTYLE HABITS THAT DAMAGE COLLAGEN Stress, Smoking, tobacco. Natural Aging process. Exposure to ultraviolet light . Unhealthy eating habits. Eating too much sugars, carbohydrate.

9. FOOD RICH IN COLLAGEN Vitamin C by A mla , gooseberry, orange, tomatoes. Citrus fruit, Berries- Black, Blue, Red Proline by cabbage , mushroom. Peanuts, Pumpkin Seed, Sesame. Glycine by (granola , almonds) Green Leafy Vegetables.

10. MEDICAL SIGNIFICANCE Cosmetic surgery. Bone grafting. Construction of artificial skin substitute. Hemostatic property. Wound healing of burn patient. Variety of dental orthopedic and surgicle purposes,

11. ABNORMALITIES OF COLLAGEN This can be due to Defect in expressions of collagen gene. Molecular defect in processing/synthesis. Defect in structure of collagen. Deficiency Vitamin C. Deficiency of Copper.

12. TYPE OF COLLAGEN AND RELATED DISORDER TYPE DISORDER I. OSTEOGENESIS IMPERFECTA, OSTEOPOROSIS, EHLER DANLOS SYNDROME ( EDS). II. CHONDRODYSPLASIAS OSTEOARTHRITIS III. EHLER DANLOS SYNDROME ( MOST SERIOUS) IV. ALPORT SYNDROME V. CLASSICAL EDS VII. EPIDERMOLYSIS BULLOSA DYSTROPHIC LYSYL OXIDASE MANKES’S DISEASE LYSYLO OXIDASE REQUIRES COPPER.

13. Que.- Major collagen present in the bone (%)? Ans – 90%

14. THANK YOU