Compartmental analysis

compartmental analysis and compartmental model, pharmacokinetic model & classification, Fate of drug in body , classification of mammilary model

1. Welcome To my Presentation

2. Presentation Topic Compartmental Analysis

3. Name Bisshojit Biswas Student of pharmacy, Final year.

4. Pharmacokinetic Model A Pharmacokinetic model may be defined as complex biological system which describes the- Movement of drugs Absorption of drugs Distribution of drugs Elimination of drugs from one or more compartments

5. Fate Of Drug In The Body ADME:- Oral Administration GI Tract Execration Intravenous Injection Circulatory system Intramuscular injection Subcutaneous injection Tissues Metabolic Sites

6. Pharmacokinetic Modeling A Model is a hypothesis using mathematical terms to describe quantitative relationships Modeling Requires: Thorough knowledge of anatomy and physiology Understanding the concepts and limitations of mathematical models Assumptions are made for simplicity.

7. Classification Of Pharmacokinetic Model

8. Classification of Mammilary Model

9. Compartment Model Describes the pharmacokinetics of drug disposition by grouping body tissues that are kinetically indistinguishable & describes the transfer of drug between body tissues in terms of rate constants. The model is an open system since drug is eliminated from the system . The amount of drug in the body is the sum of drug present in the compartments.

10. Compartmental Model Extrapolation from animal data is not possible because the volume is not a true volume but is a mathematical concept. Parameters are kinetically determined from the data.

11. Thank you