COMPRESSED TABLETS - INFORMATIVE PRESENTATION

Informative presentation about compressed tablets

1. Resident Course in Confectionery Technology
COMPRESSED TABLETS
NCA Resident Course
Walter Vink
Vink Associates

2. FUNCTION OF INGREDIENTS
CATAGORIES OF INGREDIENTS
Vehicle /Base
Binders
Lubricants
Disintegrants
Flavors and colors
Acidulants

3. TABLETING VEHICLES / BASES
BASIS FOR SELECTION
TabletingCharacteristics
Capacity
Cost

4. TABLETING VEHICLES / BASES
Most common materials
Sugar
Dextrose
Sorbitol

5. BINDERS
FUNCTION
Hold the granule together
Does not hold the table together !!!

6. BINDERS
TYPICAL MATERIALS
Corn syrup
Gelatin
Gums

7. LUBRICANTS
FUNCTION
Glidant
Anti-adhesive
Lubricant

8. LUBRICANTS
Typical materials
Magnesium Stearate
Calcium Stearate
Stearicacid
Amino Acids
Vegetable oil sterines

9. Wet Dry Direct
Granulation
Granulation
Compaction
Pulverizing Pulverizing Mixing
Wet Mixing Mixing Tableting
Granulation

10. WET GRANULATION
Pulverizing
Wet mixing <----------------------Binder & Color
Granulation
Drying
Sizing
Flavor
Dry color
Mixing <---------------------------- Acid
Active & Lubricant
Tableting

11. DRY GRANULATION
Pulverizing
Mixing <------------------------ Lubricant
Compaction
Sizing
Flavor
Dry color
Mixing <------------------------ Acid
Active ingredients
Lubricant
Tableting

13. DIRECT COMPACTION
Flavor
Dry color
Mixing <---------------------Acid
Active Ingredients
Lubricant
Tableting