Contagious ecthyma

orf, contagious pustular dermatitis ,scaby mouth

1. CONTAGIOUS ECTHYMA Submitted to: Dr. M Akram khan Submitted by: Group-1 (4 th evening) M. Faraz Mumtaz 16-arid-2893 Abdul Rehman Manzoor 16-arid-2864 Hamza Jafar 16-arid-2881

2. Introduction: Contagious ecthyma orf Infectious labial dermatitis Sore mouth Scabby mouth Contagious pustular dermatitis(CPD).

3. It is infectious disease of sheep and goats Lesions on muzzles, lips, and stomatitis on teats. Most susceptible are young Also reported in musk ox, reindeer and camel. Morbidity Mortality

4. Cont … https://www.msdvetmanual.com/integumentary-system/contagious-ecthyma/overview-of-contagious-ecthyma

5. Etiology orf virus Genus Parapoxvirus Family Poxviridae . d-DNA Similar to pseudo cowpox virus. Epitheliotropic Transmitted to human.

6. Orf virus is sensitive to Ether temperature UV light and wetting Organic substances Orf virus is resistant to: Glycerol Physical damage.

7. Economic importance Low production Less body weight Wool damage Slaughtering

8. Host range Sheep and goats Cattle Alpacas Camels Big horn sheep Reindeer Deer Squirrels

9. Transmission Contagious disease Utensils, Contaminated feed, Water , Aerosols Direct and close contact From their mother Week immunity, wound

10. zoonosis In humans orf (ore-F) During lambing, Shearing, Docking, Drenching or Slaughtering 3-7 days direct contact human to human transmission

11. Clinical signs Rise in temperature, Papules Pustules Scabs Lesions on gum Tongue and palate Also on skin of face, ears, feet, and scrotum

12. Cont … Disease is characterized by different phases: Phase-1 small papules Phase-2 pustules Phase-3 exudation Phase-4 scab and scar formation

13. a   A small red spot with no scab   b ,  c , and  d  Black scabs E bigger round scabs F Hemorrhagic orf lesion due to ruptured vesicle. https://link.springer.com/article/10.1007/s00580-017-2619-8

14. https://www.hindawi.com/journals/crivem/2013/210854/fig1

15. Diagnosis: Diagnosis is based on: characteristic lesions, clinical signs and previous history

16. Laboratory diagnostic tests Serological include: Serum neutralization, ELISAs Agar gel immunodiffusion (AGID) Complement fixation and agglutination.

17. Differential diagnosis Differential diagnosis includes: Sheep and goat pox (Capri pox) Dermatophilosis Blue tongue Foot rot FMD Papillomatosis Herpes virus infection Staph infection Actinobacillosis Ulcerative dermatosis

18. Gross lesions: multifocal proliferative and ulcerative dermatitis Around mouth and nares

19. http://agriculture.vic.gov.au/agriculture/pests-diseases-and-weeds/animal-diseases/sheep/scabby-mouth-orf-a-disease-of-sheep-and-goats

20. Histopathology: keratinocytes are markedly swollen. Multifocally, viral inclusion bodies. epidermal hyperplasia hyperkeratosis. Ballooning of keratinocytes. parakeratosis and acanthosis infiltration of neutrophils Degenerative changes

21. https://www.sciencedirect.com/science/article/pii/S0378113512005913 Normal skin balooning Rete ridges and hyperkeratosis

22. Viral Inclusion bodies in cytoplasm and hyper keratosis: Orf parapoxvirus infection from a cat scratch Jonathan Frandsen, Mike Enslow , Anneli R Bowen MD Dermatology Online Journal 17 (4): 9

23. Treatment: Self limiting. Clear in 3-4 week Antiseptic. Antibiotics in secondary infections. Lesions shed off itself. Soft, palatable food should be provided during sickness. Recovered are resistant.

24. REFERANCES: Upadhyaya , A.K, textbook of preventive veterinary medicine, udham singh nager (Uttaranchal), india . SAMUEL, W.M, CHALMERS,W.A, STELFOX, J.G, LOEWEN, A, contagious ecthyma in bighorn sheepand mountain goat in western Canada, 1975, journal of wild life disease , vol.11. Contagious ecthyma, 2015, the center for food security & public health, ames , lowa .