Cori Cycle. Definition and clinical manifestation

Cori cycle

1. Cori’s Cycle

2. Cori Cycle When anaerobic conditions occur in active muscle, glycolysis produces lactate The lactate moves through the blood stream to the liver, where it is oxidized back to pyruvate. Gluconeogenesis converts pyruvate to glucose, which is carried back to the muscles The Cori cycle is the flow of lactate and glucose between the muscles and the liver

3. The Cori Cycle Lactate from active muscle is converted to glucose in liver.

4. Pathways for Glucose

5. Lactate and alanine are glucogenic In muscle alanine is produced from pyruvate by transamination. pyruvate + glutamate  alanine + α -ketoglutarate In the liver alanine is converted back to pyruvate. In active muscle lactate builds up, passes through the blood and is converted to pyruvate in the liver. Thus, part of the metabolic burden of active muscle is shifted to the liver.