Coronary thrombosis clinical manifestation

Coronary thrombosis is formation of a blood clot inside a blood vessel of heart. Thrombosis in the heart can pave to a myocardial infarction. Coronary Thrombosis is general in high blood pressure patient, diabetic, and victims of atherosclerosis. The treatment is decreasing pain, improving blood flow to the heart muscle, and preventing irreversible damage to the heart muscle.
Coronary Thrombosis in the heart can pave to a myocardial infarction. Coronary thrombosis and myocardial infarction are sometimes availed as synonyms, although this is technically much inaccurate as the thrombosis refers to the blocking of blood vessels, while the infarction refers to the tissue death due to the consequent loss of blood flow to the heart tissue. The heart comprises many connecting blood vessels, and depending upon the location of the thrombosis, the infarction may cause no symptoms [1, 2] (Fig: 1 &2).
Fig: 1. Coronary Thrombosis
Fig: 2. Heart with blood clot
Facts of Coronary Thrombosis
Studies in Thrombosis and Hemostasis, Thrombosis and Haemostasis, Arteriosclerosis, Thrombosis, and Vascular Biology, Clinical and Applied Thrombosis/Hemostasis were a key investigation topics and research are carried out to encounter problems in these fields

1. Coronary Thrombosis: Clinical Manifestation & Case Study BY Dr. S.SREEREMYA FACULTY OF BIOLOGY

2. INTRODUCTION Coronary thrombosis is formation of a blood clot inside a blood vessel of heart. Thrombosis in the heart can pave to a myocardial infarction. Coronary Thrombosis is general in high blood pressure patient, diabetic, and victims of atherosclerosis. The treatment is decreasing pain, improving blood flow to the heart muscle, and preventing irreversible damage to the heart muscle. Coronary Thrombosis in the heart can pave to a myocardial infarction. Coronary thrombosis and myocardial infarction are sometimes availed as synonyms, although this is technically much inaccurate as the thrombosis refers to the blocking of blood vessels, while the infarction refers to the tissue death due to the consequent loss of blood flow to the heart tissue. The heart comprises many connecting blood vessels, and depending upon the location of the thrombosis, the infarction may cause no symptoms [1, 2] (Fig: 1 &2). Fig: 1. Coronary Thrombosis Fig: 2. Heart with blood clot Facts of Coronary Thrombosis Studies in Thrombosis and Hemostasis , Thrombosis and Haemostasis, Arteriosclerosis, Thrombosis, and Vascular Biology, Clinical and Applied Thrombosis/ Hemostasis were a key investigation topics and research are carried out to encounter problems in these fields

3. Health surveys reported of a case of intracoronary thrombosis causing significant myocardial ischemia during elective coronary angiography, treated promptly with the local brinolytic therapy, in a patient with severe vasovagal reaction during femoral artery puncture [3]. CORONARY ARTERY DISEASES Understanding of the pathophysiology of coronary artery disease (CAD) has undergone quiet a remarkable evolution. Researchers review how these advances have altered our concepts of and clinical approaches to both the chronic and acute phases of CAD. Previously considered that a cholesterol storage disease, recently it was assessed that atherosclerosis as an inflammatory disorder [4]. The appreciation of arterial remodelling (compensatory enlargement) has typically expanded attention beyond stenosis evident by angiography to encompass the biology of nonstenotic plaques. Revascularization effectively relieves ischemia, but we now recognize the need to attend to non-obstructive lesions as well. Aggressive management of modifiable risk factors to reduces cardiovascular events and should accompany appropriate revascularization. Researchers now recognize that disruption of plaques that may not produce critical stenosis causes many acute coronary syndromes (ACS). The disrupted plaque represents a “solid-state” stimulus to the thrombosis.

4. Alterations in circulating prothrombotic or antifibrinolytic mediators in “fluid phase” of the blood can also predispose toward the ACS. Recent results have quietly established the multiplicity of “high-risk” plaques and the widespread nature of inflammation in patients prone to develop ACS. These findings challenge our traditional view of coronary atherosclerosis as a segmental or localized disease. Thus, the treatment of ACS should involve 2 overlapping phases: first, addressing the culprit lesion, and second, aiming at rapid “stabilization” of the other plaques that may produce recurrent events. The concept of the “interventional cardiology” must typically expand beyond mechanical revascularization to embrace preventive interventions that forestall future events [5]

5. Clinical and morphologic findings are delineated in a 22 year old man with prolonged thrombocytosis, and coronary and splenic arterial thrombi causing myocardial and splenic infarcts. The absence of the pre-existent extensive coronary atherosclerosis, the presence of thrombus in more than one epicardial artery and in several intramural coronary arteries, the presence of arterial thrombosis in a noncoronary artery (splenic) and the absence of another apparent cause of arterial thrombisis are evidences that the intra-arterial clotting in this patient was related to the severe thrombocytosis. A review of the reported cases of vascular occlusion allied with thrombocytosis indicates that thrombi have infrequently been confirmed as the mechanism of the vascular occlusion. Although the frequency of vascular thrombisis in patients with thrombocytosis has not yet been established, it is clear that vascular thrombosis can be a consequence of thrombocytosis and, as it is mainly demonstrated by the present patient, that the coronary artery may be the site of the vascular occlusion, a here to fore unconfirmed event [6

6. Research & Review: Management of Cardiovascular and Orthopedic Complications, Coronary Thrombosis: Clinical Manifestation & Case Study S.Sreeremya , 2018.Vol1(1):1-5.