correlation between lifestyle factors and endometrial cancer

correlation between lifestyle factors and endometrial cancer

1. STUDY TITLE- CORRELATION BETWEEEN LIFESTYLE FACTORS AND ENDOMETRIAL CANCER. Name of principal investigator- Dr Shriya Sharma Junior Resident Department of Obstetrics and Gynaecology Phone number- 9706369444 Email - [email protected]

2. Introduction The incidence and prevalence of endometrium cancer is increasing worldwide. Endometrial cancer is the most common malignancy of the female genital tract in developed countries. The worldwide obesity epidemic may fuel an increase in endometrial cancer, one of the most adipose-sensitive malignancies. Being overweight or obese, not doing enough exercise and having hormonal imbalances can increase the risk of metabolic syndrome which in itself can increase the risk of malignancy.

3. Women who are 10-20 kg overweight have a 3-fold risk, which increases to 10-fold if they are more than 25 kg overweight, because of the increased peripheral conversion of andro- stenedione to oestrone by aromatisation in fat. The combination of diabetes, obesity and hypertension, in association with endometrial carcinoma, is called the corpus cancer syndrome

4. Lifestyle factors play an important role in the development of endometrial cancer. It's crucial to lead a healthy lifestyle by maintaining a balanced diet, staying active, and keeping an eye on hormonal health. These steps can help lower the risk of endometrial cancer and promote overall well-being. Here with presenting a series of endometrial cancer over a period of one year.

5. Aims & Objectives To find out the lifestyle risk factors associated with endometrial malignancy To find out the prevalence of endometrial cancer due to lifestyle changes.

6. Material and Methods Study center - The study will be conducted in the Department of Obstetrics and Gynaecology and Department of Pathology in a Tertiary Health Care Centre in Navi Mumbai. Study population -Patients coming with complaints of post-menopausal, peri menopausal and abnormal uterine bleeding with confimed histopathology report of endometrial cancer will be taken in the study.

7. Study procedure- -Study will commence after the ethics committee approval. -Our study sample would comprise of patients with cancer endometrium -Patients will be selected with the following inclusion and exclusion criteria

8. INCLUSION CRITERIA -Women diagnosed with endometrial cancer from clinical and histopathological evidences EXCLUSION CRITERIA -Women who were treated initially by chemotherapy, radiotherapy or its combination. Study duration- - One year(August 2022- August 2023)

9. Assessment Parameters The study will be conducted in the department of Obstetrics and Gynaecology. One-year retrospective data will be analysed. Patients coming with complaints of post-menopausal, peri menopausal and abnormal uterine bleeding will be taken in the study.

10. Detailed history on patients age, parity, risk factors, comorbidities, weight, height, body mass index, family history of malignancy will be analysed. In addition symptomatology, histopathology of the endometrial biopsy along with post operative histopathology report of the specimen removed during the surgery will be evaluated.

11. ANNEXURES Case record form Name Age Marital status Chief complaints Obstetric history Menstrual history Past history (Medical & surgical) Endometrial biopsy reports Histopathological reports General examination Systemic Examination Local examination Per vaginum and per speculum examination