Creatinine clearance

Cr Clearance?

1. What is creatinine clearance? Dr. Haji Bahadar,PharmD , PhD Assistant Professor, KMU-IPMS

2. Topics What is creatinine? Why is it important to check blood creatinine levels? What is creatinine clearance? How creatinine clearance can be measured ?

3. What is creatinine? Creatinine is a chemical waste molecule that is generated from muscle  metabolism. Creatinine is produced from creatine, a molecule of major importance for energy production in muscles. Creatinine is transported through the bloodstream to the kidneys. The kidneys filter out the creatinine.

4. Creatine   Creatine   is a nitrogenous organic acid that occurs naturally in vertebrates. Its main role is to facilitate recycling of adenosine triphosphate (ATP), the energy currency of the cell, primarily in muscle and brain tissue. Creatine is not an essential nutrient as it is naturally produced in the human body from the amino acids  glycine  and  arginine . Creatine, synthesized in the liver and kidney, is transported through the blood and taken up by tissues with high energy demands, such as the brain and skeletal muscle.

5. Why is it important to check blood creatinine levels? The kidneys maintain the blood creatinine in a normal range ( male: 0.6 to 1.2 milligrams (mg) per deciliter ( dL ). Creatinine is a reliable indicator of kidney function. Elevated creatinine level show impaired kidney function or kidney disease.

6. Creatinine Clearance Creatinine clearance means to compare the creatinine level in a 24-hour urine sample with the creatinine level in your blood. Creatinine clearance also helps estimate the glomerular filtration rate ( GFR). This test provide information about the severity of kidney disease. The amount of blood the kidneys can make creatinine-free each minute is called the creatinine clearance . Creatinine clearance in a healthy young person is about 125 milliliters per minute -- meaning each minute, that person's kidneys clear 125 mL of blood free of creatinine.

7. How creatinine clearance can be measured ? The creatinine clearance can be calculated by a formula using serum (blood) creatinine level, patient's weight, and age. 1. COCKCROFT-GAULT Formula (not clinically used). C Cr =(l 40–age) x weight)/(72xS Cr )}x 0.85 (if female) Abbreviations/ Units C Cr  (creatinine clearance) = mL/minute Age = years Weight = kg SCr (serum creatinine) = mg/ dL https:// www.kidney.org/professionals/KDOQI/gfr_calculatorCoc

8. 2. Creatinine clearance can also be more directly measured by collecting a 24-hour urine sample and then drawing a blood sample. The creatinine levels in both urine and blood are determined and compared using a formula. Decreased creatinine clearance indicates decreased glomerular filtration rate (GFR). This can be due to conditions such as progressive renal disease.

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