Current HPV Vaccine Recommendation 2022

Current HPV Vaccine Recommendation 2022

1. Current HPV Vaccine Recommendation 2022 Dr Sadhna Gupta Dr Ragini Agarwal Dr Sharda Jain Dr Sweta Balani International Agency for research of Cancer NORTH INDIA GYNAECOLOGIST FORUM (NIGF ) / Delhi Gynaecologist Forum (DGF)

2. Protection from HPV vaccination- against Various Cancers Virtually all Cases

3. Most deadly Cancer Cervix Often referred to as the ‘Silent killer’ and almost 100% preventable.

4. Inspite of being preventable…. Cervical Cancer burden is increasing 90% of whom live in low- and middle-income countries (LMICs). More than 95% of cervical cancers are caused by oncogenic types of human papillomavirus (HPV). 2018 Projected in 2030 New Cases 5,70,000 7,00,000 Annual Deaths 3,11,000 4,00,000 Global Cancer Observatory International Agency for Research on Cancer, WHO

5. Every 9 Minutes A women Loses her battle to Cervical Cancer which is preventable Do not let it happen to You or your Daughter

6. HPV V accine is very safe and highly effective (93 -100%) in preventing C ervical precancer and Cancer

7. Global Call - May 2018

8. Current HPV Vaccination in India   G irls V accinated   - <1% N ational Family Health S urvey 2019-2021

9. Challenge in HPV Vaccination E xpensive Multiple Doses Shortage of Vaccine supply Not included in vaccination Schedule

10. This make vaccination program logistically more complex, more expensive, and less resilient WHO study shows o nly 13% received 2 nd dose in adolescent category .

11. WHO-SAGE recommended HPV vaccine dose schedules (2022) One or two-dose schedule  for the primary target of girls and boys aged  9-14 One or two-dose schedule  for young adolescent women and men aged  15-20 Two doses with a 6-month interval for women and men older than 21 . Immunocompromised individuals, including those with HIV , should receive three doses if feasible, and if not at least two doses .

12. Evidence for Single-Dose HPV Vaccination Strong growing evidence that an effect similar to 3- and 2- doses could be achieved with single-dose of HPV vaccination. Results from cohort studies: the IARC India trial with a quadrivalent vaccine , and the Costa Rica Trial with a bivalent vaccine , have shown comparable efficacy between single-dose and multi-dose schedules, with sustained antibody levels for at least 11 years after vaccination. Recent evidence from randomized single-dose vaccine trials, such as the KEN SHE and DoRIS trials in Sub-Saharan Africa.

13. HPV 16 Ab response at 10 yr : 96% of single dose recipients had detectable antibody Ab titre in single dose recepients was 15 times higher than natural immunity HPV 18 Ab response at 10 yr 97% of single dose recipients had detectable antibody Ab titre in single dose recepients was 10 times higher than natural immunity Evolution of immune responses against HPV 16 /18 over 10 yrs in the recipients of a single or three doses (M9ELISA) Vaccine. 2023 Jan 4;41(1):236-245. doi : 10.1016/j.vaccine.2022.11.044 .

14. 10-year trends in neutralizing Ab against HPV 16 and 18 Vaccine. 2023 Jan 4;41(1):236-245. doi : 10.1016/j.vaccine.2022.11.044 .

15. Launch of Indigenous Vaccine September 2022…. Adequate supply of new vaccine will be a huge steps to accelerate cervical in LIMC and globally

16. These could be a Game-Changer for the prevention of the disease; seeing more doses of the life-saving VACCINE reaching more girls. Single Dose of Low cost HPV Vaccination

17. School based program in 7 Indian State is in pipeline Vaccine with 2 dose schedule in 3 States ( Chhattisgard , Karnataka, Maharashtra) Vaccine with 1 dose schedule in 4 States ( Mizorum , Tamilnadu , Uttarakhand & Himachal Pradesh)

18. Need Political Will to give extensive coverage of HPV vaccine to adolescent Girls Failure to do so is an injustice to the generation of girls and young women who may be at risk of cervical cancer.” says WHO – Deputy Director

19. IARC projected the health benefits and potential economic impact of a national single-dose HPV vaccination programme for girls in India The study found that such a vaccination programme could substantially reduce the incidence of cervical cancer, to below the incidence rate established by WHO as the threshold for the elimination of cervical cancer as a public health problem

20. 3 doses for all Immunocompromised individuals, including those with HIV

21. WHO Assistant Director-General Dr Princess Nothemba ( Nono ) Simelela commented, “I firmly believe the elimination of cervical cancer is possible with single dose HPV vaccination for adolescents .. Dr Neerja Bathla Dr Shankar Narayan Feel the same

22. 90/70/90 Cervical Cancer Prevention Program This single-dose recommendation has the potential to take us faster to our goal of having 90 per cent of girls vaccinated by the age of 15 by 2030.” Dr Sadhna Gupta Dr Ragini Agarwal Dr Sharda Jain Dr Sweta Balani

23. India’s 1 st Indigenous qHPV Vaccine

24. GENDER NEUTRAL HPV VACCINE . One - Dose for both Girls & Boys should be considered for Prevention of Cervical Cancer

25. Thank You