Development and evaluation of poly herbal oint

Pres

1. DESH BHAGAT UNIVERSITY
SCHOOL OF PHARMACY
DEVLOPEMENT AND EVALUATION OF POLY HERBAL OINTMENT FOR WOUND HEALING
ACTIVITY
SUBMITTED BY
NAME:AAMIR NAZIR
ROLL NO:20390451111
IN PARTIAL FULFILMENT OF THE OF THE REQUIRED DEGREE OF
BACHELORS OF PHARMACY

UNDER THE GUIDES OF
M.s MOHITA THAKUR (ASSISTANT PROFESSOR)

2. Submitted under
Ms. Mohita thakur
(ASSISTANT PROFESSOR)
                                         Submitted by
                                     Name: Aamir nazir
                                   Roll no : 20390451111
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3. Develpoment and evaluation of polyherbal
ointments for wound healing
Wound is a physical trauma where the skin is torn, cut or punctured. Several drugs
obtained from plant sources are known to increase the healing of different types
of wounds. The present study was aimed to develop a herbal formulation using
herbs which has been proved to enhance the cell proliferation, cell migration and
alleviate the inflammation and infection thus hasten the healing process.
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•Herbal medicines are plant based medicines made from differing
combinations of plant parts. E.g. leaves, flowers and roots.

4. Herbal Ointments
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Ointments are semisolid preparations used for
topical application to the skin or mucous
membranes. They are typically composed of a
base, which can be oily, greasy, or water-
soluble, and active ingredients, such as
medications or herbal extracts.
Ointments are used for various purposes,
including treating skin conditions like eczema,
psoriasis, or minor cuts and burns, as well as
for cosmetic applications like moisturizing and
protecting the skin. They provide a protective
barrier on the skin surface and can deliver
medication directly to the affected area.

5. Advantages
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High low/minimum cost
Complete accessibility
Enhanced tolerance
More protection
Fewer side effects
Potency and efficacy is very high

6. Disadvantages
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Not able to cure rapid sickness and accidents
Risk with self-dosing
Complexity in standardizations.
Risk of Contamination

7. Types of wound healing
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Primary Intention Healing
Secondary Intention Healing
Tertiary Intention Healing (Delayed Primary
Closure)
Healing by Granulation
Healing by Epithelialization
Healing by Contraction

8. Factors effecting wound healing
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Age: Older individuals generally experience slower wound
healing compared to younger people
Nutritional Status: Adequate nutrition, including sufficient
intake of protein, vitamins and minerals is essential for optimal
wound healing
Blood Supply: Good blood circulation is critical for delivering
oxygen and nutrients to the wound site and removing waste
products
Infection: W ound healing can be delayed or impaired by the
presence of infection
Chronic Diseases: Certain chronic conditions, such as diabetes,
hypertension, autoimmune disorders, and vascular diseases, can
interfere with the body's ability to heal wounds properly.

9. Phases involved in wound healing
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Normal wound healing involves there are 4 overlapping phases.
Hemostasis phase
Inflammatory phase
Proliferative phase
Remodeling phase

10. Role of plant for
wound healing
activity
•The wound healing activities of plants have since been
explored in folklore. Many ayurvedic herbal plants have
a very important role in the process of wound
healing. Extensive research has been carried out in the
area of wound healing management through
medicinal plants.
•Aloe Vera: Aloe vera has anti-inflammatory,
antimicrobial, and wound-healing properties.
•Lavender: Lavender oil has antibacterial and anti-
inflammatory properties
•Tea Tree Oil: Tea tree oil has antimicrobial and anti-
inflammatory properties. It can be applied topically to
wounds to prevent infection and promote healing.
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11. Uses of plants
Aloe vera
Aloe vera has been used for centuries for its medicinal properties and
is a popular ingredient in many pharmaceutical products.
Skin Soother: Aloe vera gel is a common ingredient in ointments
and creams used to treat a variety of skin conditions, including
sunburn, minor cuts, scrapes, and insect bites.
Wound Healing: Studies have shown that aloe vera can help
accelerate wound healing by promoting collagen production and
reducing inflammation.
Digestive Aid: Aloe vera juice is sometimes used as a laxative to treat
constipation.
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12. Lavender
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Lavender has a long history of medicinal use and
finds its way into various pharmacy applications
Anxiety and Sleep: Lavender oil, extracted from
the flower, is commonly used in aromatherapy
for its calming properties. It's believed to ease
anxiety and promote better sleep
Skin Conditions: Lavender's potential antiseptic
and anti-inflammatory properties make it a
helpful addition to creams and ointments for
minor skin irritations, burns, and insect bites.

13. Tea tree oil
•Tea tree oil, derived from the Melaleuca alternifolia plant, has become
a popular ingredient in pharmacy due to its potential antiseptic and
antimicrobial properties
•Topical Antiseptic: Tea tree oil's possible antimicrobial properties
make it a candidate for use in diluted solutions to help prevent
infection in minor wounds, scrapes, and burns.
•Acne Treatm ent: Studies suggest tea tree oil may be beneficial in
managing acne vulgaris. Its potential anti-inflammatory and
antimicrobial properties might help reduce blemishes
•tea tree oil holds potential for topical applications in pharmacy,
particularly as a diluted antiseptic and in acne treatment products.
However, it's crucial to remember the limitations in research and the
importance of proper dilution to avoid irritation.
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14. Morphology of plants
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Plant morphology is the scientific study of the physical form
and external structure of plants. It's distinct from plant
anatomy, which focuses on the internal structure of plants,
usually at the cellular level.
Plant identification: By examining a plant's morphological
features like its leaves, stems, flowers, and fruits, scientists
and botanists can identify different plant species.
Agriculture: Knowledge of plant morphology helps in
optimizing crop yield and quality. For instance,
understanding stem structure is crucial for pruning
techniques, while leaf morphology can influence a plant's
light interception and photosynthetic efficiency.

15. Characterization of
herbal drugs
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Characterization of herbal drugs involves a comprehensive assessment of their
identity, quality, purity, and potency. Here are some key aspects of characterization.
Botanical Identity
Chem ical Com position
Q uality Control
Purity
Potency

16. Marketed ointment
formulation for wound
healing activity
There are several commercially available
ointments formulated specifically for wound
healing activity.
•Neosporin
•Bactroban
•Silvadene (Silver Sulfadiazine)
•Medihoney
•Derm abond
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17. Conclusion
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W ound healing is a complex and
continuous process that begins immediately after
injury, followed by homeostasis, blood clotting,
inflammation, proliferation and remodeling
phases. All these phases can promote or prolong
healing by influencing external or internal factors
including infection sex hormones and nutrition.
Delay in healing process
increases the possibility of getting infected,
improper recovery, and formation of unpleasant
scar.
The study concludes that the poly herbal extract
obtained by the dried powders of Neem leaves,
Tridax leaves, Aloe gel and Turmeric rhizome
posses antimicrobial activity. Incorporation of the
poly herbal extract into ointment base at 4% (F4)
demonstrated ideal physiochemical
characteristics. These findings could justify the
inclusion of this formulations in the management
of wound healing.

18. REFRENCES
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Meria MD, Pinky Sarmah, Dhilleswara Rao V et al., W ound Healing:
Concepts and Updates in Herbal Medicine. International Journal of Medical
Research & Health Sciences. 2018; 7(1): 170-181.
Maver T, Maver U, Stana Kleinschek K et al., A review of herbal medicines in
wound healing. International Journal of Dermatology. 2015; 54(7): 740-751.
Terence JR. Use of herbal medicines in wound healing: a perspective paper.
Lower Extremity W ounds. 2003; 2(1): 22-24.
Augustine A, Boadu, Alex A. Documentation of herbal medicines used for
the treatment and management of human diseases by some communities in
southern ghana. Evidence Based Complementary and Alternative Medicine.
2017; 1-12.
Ferrero-Miliani L, Nielsen OH, Andersen PS et al., Chronic Inflammation:
Importance of NOD2 And NALP3 In Interleukin-1betaGeneration.
Clin.Exp.Immunol. 2007; 147(2).

19. Thankyou