Development of stomach

embryology

1. Development
of the
Stomach

2. •Stomach develops from distal part of foregut.
•It is initially a simple tubular midline structure.
•Around the middle of the fourth week, a slight
dilation indicates the site of the future stomach.
It first appears as a fusiform enlargement of the
caudal part of the foregut.
•This primordium soon enlarges and broadens
dorsally. This is due to differential growth on
dorsal side. During the next 2 weeks the dorsal
border of the primitive stomach grows faster
than its ventral border; this demarcates the
greater curvature of the stomach.

3. Lateral view of developing stomach in successive stages
showing differential growth dorsally.

4. Rotation of the
developing stomach
•During development the developing
stomach rotates along two axes.
•These rotations determine the final
position of stomach in left hypochondrium.

5. First rotation
•90 degrees clockwise Differential growth
•original left side becomes ventral surface
•original right side becomes dorsal surface.

6. Second rotation anterior-posterior axis
•Before rotation, the cranial and caudal ends of
the stomach are in the median plane.
•After rotation, the stomach assumes its final
position with its long axis almost transverse to
the long axis of the body.

7. Mesenteries of the stomach
•The stomach is suspended from the dorsal wall
of the abdominal cavity by a dorsal mesentery
called dorsal mesogastrium. This mesentery is
originally very thick and lies in the median
plane. Later on it is shifted to left side due to
rotation of stomach.
•A ventral mesentery called ventral
mesogastrium attaches the stomach with
anterior abdominal wall. It is in fact septum
transversum.

8. Transverse section of abdominal cavity of a
developing embryo in 4th week at the level of
stomach.

9. •Isolated clefts or spaces develop in the mesenchyme
forming the thick dorsal mesogastrium during fourth
week of embryonic period. The clefts soon coalesce to
form a single cavity called omental bursa or lesser
sac.

10. •Later on as the stomach rotates along longitudinal
axis, dorsal mesogastrium is carried to the left thereby
enlarging the bursa. Now there is a large recess of the
peritoneal cavity behind stomach. The omental bursa
expands transversely and cranially and soon lies
between the stomach and the posterior abdominal
wall. This pouch like bursa (L., purse) facilitates
movements of the stomach).
•At this stage, omental bursa is related anteriorly to
stomach and posteriorly to posterior abdominal wall.
Its left lateral boundary is dorsal mesogastrium. It is
wide open on to the right side.

11. •Development of lesser sac or omental
bursa. Successive stages

12. •The primordium of spleen appears in 5th week
of development as a mesodermal proliferation
between the two leaves of dorsal
mesogastrium.
•As the omental bursa expands and swings to
the left side, a portion of dorsal mesogastrium
behind spleen fuses with the peritoneum of
posterior abdominal wall.
•The fused layers are absorbed and disappear.

13. •Thus the tail of pancreas becomes
retroperitoneal.
•Remember that pancreas develops in
dorsal mesoduodenum, but later on its tail
expands into dorsal mesogastrium.

15. •Spleen maintains its intraperitoneal
position.
•It is connected with dorsal body wall in the
region of left kidney by lienorenal ligament
(Lien L., spleen) and to stomach by
gastrosplenic ligament.
•These two ligaments are nothing but parts
of dorsal mesogastrium.

16. •Later on as stomach enlarges and rotates
around anterio-posterior axis the dorsal
mesogastrium forming the left wall of omental
bursa is thrown downward.
•It grows enormously downward forming anterior
and posterior layers of dorsal mesogastrium in
front of transverse colon and small intestinal
loops like an apron. Anterior layer is hanging
down from greater curvature of stomach and
posterior layer from posterior abdominal wall.
•The space between the two layers is called
inferior recess of omental bursa.

18. •Later on these anterior and posterior layers
fuse to form a single sheet hanging downward
from greater curvature of stomach.
•The posterior layer also fuses with the
mesentery of transverse colon.
•The fused apron of dorsal mesogastrium
hanging downward from greater curvature of
stomach is now called greater omentum (L., fat
skin).

19. •This is a four-layered membrane. It
overhangs the developing intestines.
•The inferior recess of omental bursa
disappears as the anterior and posterior
layers of greater omentum fuse.

20. •Ventral mesogastrium is actually septum
transversum. It is between foregut and anterior
abdominal wall. Later on the liver bud enters in
septum transversum and the liver grows within
septum transversum. As a result of the
enormous growth of liver, the mesenchyme of
septum transversum becomes stretched and
membranous thus forming
1.falciform ligament, between anterior
abdominal wall and liver
2.the peritoneal coving forming the false capsule of
liver
3.and lesser omentum between liver and
stomach/upper part of duodenum.

22. •The free margin of falciform ligament contains
umbilical vein, which after birth is obliterated to
form ligamentum teres hepatic.
•Lesser omentum between liver and stomach is
called hepato-gastric ligament, while the part of
lesser omentum between liver and duodenum
is hepato-duodenal ligament.

23. •The free margin of lesser omentum
between liver and duodenum contains bile
duct, portal vein and hepatic artery. In
adults the right border of lesser omentum
forms the anterior boundary of epiploic
foramen. Epiploic foramen is the
connection between lesser sac and
greater sac.

24. •Liver is completely covered by peritoneum
forming the false capsule of liver. It is derived
from the mesenchyme of septum transversum.
•Superiorly a triangular portion of liver is not
covered by peritoneum. This triangular area is
called the bare area of liver. It is covered by
diaphragm. Here liver is attached to diaphragm
by areolar tissue.
•Remember that diaphragm also develops from
septum transversum.

26. •Stomach is supplied by
1.left gastric artery – a branch of celiac artery
2.right gastric artery – a branch of common
hepatic artery – a branch of celiac artery
3.right gastro-epiploic – a branch of gastro-
duodenal artery – a branch of common
hepatic artery – a branch of celiac artery
4.left gastro-epiploic – a branch of splenic
artery – a branch of celiac artery

27. Development
of the
Duodenum

28. •Duodenum begins to develop in the early part
of fourth week.
•It (epithelium) develops from caudal part of
foregut and cranial part of midgut.
• All the other layers of duodenum are derived
from surrounding splanchnic mesenchyme.
•The junction of the two parts of the duodenum
is just distal to the origin of the liver
diverticulum and in adult it is common bile duct.
•At this junction the ventral and dorsal
pancreatic buds are also developing.

29. •Duodenum grows rapidly, forming a C-shaped loop
ventrally.

30. •As stomach rotates 90 degrees in clockwise
direction around its longitudinal axis to the left,
duodenal loop rotates to the right.
•This rotation together with rapid growth of
pancreas swings duodenum from its initial
midline position to the right.

31. •Duodenum and pancreas are pressed against
posterior abdominal wall. The right leaf of
dorsal meso-duodenum fuses with parietal
layer of peritoneum. The two layers
subsequently disappear. Duodenum and
pancreas become retroperitoneal structures.
•Mesoduodenum disappears entirely except in
the region of pylorus of stomach, where a small
portion of duodenum (duodenal cap) retains its
mesentery and remains intraperitoneal.

32. •Transverse sections 5
th
and 7
th
week embryo

33. •During the fifth and sixth weeks, the lumen of
duodenum becomes progressively smaller and
is temporarily obliterated because of the
proliferation of its epithelial cells. Normally
vacuolization occurs because of degeneration
of the epithelial cells. As a result, the
duodenum normally becomes re-canalized by
the end of the embryonic period. But
sometimes the occlusion persists leading to
duodenal stenosis.

34. •Because duodenum is developing from
foregut and midgut, it is supplied by
branches of celiac and superior
mesenteric arteries.
1.right gastric - a branch of hepatic artery - a
branch of celiac trunk.
2.supra-duodenal – arises from either gastro-
duodenal, hepatic artery, or right gastric
artery. Gastro-duodenal and right gastric are
branches of hepatic artery. Hepatic artery is
branch of celiac trunk.

35. 1.right gastro-epiploic - a branch of
hepatic artery - a branch of celiac
trunk.
2.superior pancreatico-duodenal - a
branch of hepatic artery - a branch of
celiac trunk.
3.inferior pancreatico-duodenal – a
branch of superior mesenteric artery.