Diabetis insipidus

Diabetes insipidus (DI) is a condition characterized by large amounts of dilute urine and increased thirst.

1. DIABETES
INSIPIDUS
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2. DEFINITION
“Diabetes insipidus is the disorder of
the posterior pituitary gland that is
characterised by a deficiency of
Antidiuretic hormons”
It is mainly characterised exessive
thirst and large volume of dilute
urine.

3. CAUSES
•Any head trauma.
•Brain tumor.
•Surgical ablation or irradiation of the
pituatary gland.
•Infection of the central nervous system.
•Any tumor.
•Fialure of renal tubules to respond to
ADH.

4. PATHOPHYSIOLOGY
Due to any cause
Abnormalities of the posterior pituitary
gland
Deficient production of vasopresin

5. 1
Abnormally large volume of dilute urine
are excreted.
DIABETES INSIPIDUS

6. CLINICAL MENIFESTATION
•Polydipsia.
•Large volume of dilute urine excreted.
•Water like urine.
•Severe dehydration.
•Weight loss.
•Hypernatremia.

7. ASSESSMENT
•Physical examination.
•Sign and Symptoms.
•The Fluid Deprivation Test.
•Plasma and urine osmolarity study.
•SERUM Osmolarity.
•All Blood test.

8. MEDICAL MANAGEMENT
•Desmopressin.
•Intramuscular administration of ADH
•Clofibrate.-a hypolipidemic agent
•Chlorprapamide.-diabenese.
•Thiazide –diuretics.

9. 1
•If diabetes insipidus is renal in origin..
•-Thiazide.
•-Mild salt depletion.
•-Prostaglandin inhibitors.

10. THANK
YOU
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