DIAGNOSIS THE PREGNANCY
In first trimester
In second trimester
In third trimester
FIRST TRIMESTER (FIRST 12 WEEKS)
Subjective Sentence
Amenorrhoea –Abrupt cessation of
menstruation at 4
th
week
Morning sickness (Nausea and vomiting) from
4
th
–14
th
week
Frequency of micturition (Bladder irritability
Breast discomfort
Fatigue
Objective sign
•Breast changes -valuable only in primigravidae
•Per abdomen
•Pelvic changes
•Jacquemier’s or chadwick’s sign
•Vaginal sign
•Cervical signs -as early as 6
th
week (Goodell’s
sign)
•Uterine signs : (a) Size, shape and consistency
(b) Hegar’s sign
(c) Palmer’s sign
IMMUNOLOGICAL TESTS FOR
DIAGNOSIS OF PREGNANCY
•Principle : Pregnancy tests depend on
detection of the antigen (hCG) present in
the maternal urine or serum with antibody
either polyclonal or monoclonal available
commercially.
(A) Immuno assays without radioisotopes
•Agglutination inhibition tests –Using latex
(L.A.I.)
•Principle of agglutination inhibition tests
•Direct agglutination test (hCG direct test)
•Enzyme-linked immunosorbent assay (ELISA
•Fluoroimmuno assay (FIA)
(B) Immuno assay with radiosotopes
•Radioimmunossay (RIA) -used for determining
the doubling time of hCG (ectopic pregnancy
monitoring)
•Immuno-radiometric assay (IRMA) -detect
hCG as low as 0.05 mIU/ml
Selection of time
Collection of urine
Other uses of pregnancy tests
Ultrasonography
SECOND TRIMESTER (13 -28 WEEKS)
Symptoms:
•subjective symptoms –such as nausea,
vomiting and frequency of micturition usually
subside
•Quickening (feeling of life)
•Progressive enlargement of the lower
abdomen
General Examination
oChloasma : Pigmentation over the forehead and
cheek
oBreast changes -enlarged with prominent veins,
Secondary areola, Montgomery’s tubercles are
prominent and extended, Colostrum
oAbdominal examination
•Inspection
•Palpation
•Auscultation-Uterine souffle -soft blowing and
systolic murmur heard low down at the sides of the
uterus, best on the left side; Funic of fetal soufflé is due
to rush of blood through the umbilical arteries
oInvestigations
•Sonography
•Fetal organ anatomy
•Magnetic Resonance Imaging (MRI
LAST TRIMESTER (29-40 WEEKS)
Symptoms
(1) Amenorrhoea persists
(2) Enlargement of the abdomen is progressive
(3) Lightening –At about 38
th
week
(4) Frequency of micturition
(5) Fetal movements
SIGNS
•Cutaneous changes
more prominent with
increased pigmentation
and striae
•Uterine shape
changed from cylindrical
to spherical beyond 36
th
week.
•Fundal height •Symphysis fundal
height (SFH) The
upper border of the
fundus is located by the
ulnar border of the left
hand and this point is
marked
•Braxton-Hicks
contractions are more
evident.
•Fetal movements are
easily felt