Diformates vs Formic Acid (Liquid & Solid).pdf

Formic acid using as feed

1. Acidifiers place of impact
pH reduction
•Organic acids on the carrier
•Liquid acidifiers (water hygiene)
•Diformate
Antibacterial effect
Antimicrobial
&
Palatability effect
•Organic acids on the carrier
•Liquid acidifiers (water hygiene)
•Organic acids salts
•Organic acids salts
•Coated/Protected acids
•Diformate

2. Formic acid content in the gut
Kirsch, 2010 Mariboet al., 2000
Gut section
Formic acid-Dosage [%]
0.5 0.7
[mg kg
-1
] [mmol kg
-1
]
Stomach
1177 ± 363 [100%]18.1 [100%]
Small intestine
65 ± 19 [5.5%!] 0.8 [4.4%!]
Large intestine 0
0

3. Theoretical recovery rates

4. Recovery of diformate in the gut0
20
40
60
80
100
StomachDuodenum Jej 1-2Jej 3-5Jej 6-10
relative formate recovery (%)
Mroz et al., 2000

5. Recovery comparison small intestine
0
10
20
30
40
50
60
70
80
90
Formic acid Benzoic acid Diformate
Recovery of organic acids/salts in the small
intestine in %
Mroz et al., 2000; Maribo et al., 2000; Kirsch, 2010; DSM, 2016

6. Recovery comparison small intestine
0
10
20
30
40
50
60
70
80
90
Formic acid Benzoic acid Diformate
Recovery of organic acids/salts in the small
intestine in %
Mroz et al., 2000; Maribo et al., 2000; Kirsch, 2010; DSM, 2016

7. Difference in active ingredients
Acid Mix (purity?)
Formate/Formic Acid
(70/80%)
Adsorbant
(clay, silica, vermicullite,…)
Crystallization mineral
(K/Na)

8. -50
-40
-30
-20
-10
0
10
20
30
40
50
PREFERENCE IN COMPARISON TO REFERENCE DIET
INCLUSION
Dietary preferences of acids in piglets
0,5 %1%1,5 %2%0,25%
*
*
* *
*
*
*
*
*
*
Dietary preferences of acids in piglets
Modified after Suarez et al., 2010
Reference
diet

9. Holo Analysis I
All Acidifier, incl. Formi(n= 658)
•Feed Intake: +1.21%
•Weight Gain: +5.48%
•FCR: -3.69%
Formi(n=59)
•Feed Intake: +3.50%
•Weight Gain: +8.68%!
•FCR: -4.24%
Rosen, 2008

10. Holo Analysis Update II
Mellor, 2008/Rosen, 2009
FORMI Calcium
formate
Citric acidFormic
acid
Fumaric
acid
Trials 59 26 64 32 103
Dosage
range kg/t
4.0 - 72 5.0 - 27 1.8 - 45 2.5 - 25 1.2 - 40
Dosage
mean kg/t
16.5 15.1 15.6 10.4 18.1
+feed % 3.52 -0.59 0.24 1.15 0.97
+weight % 8.67 1.68 3.29 4.94 4.00
FCR % -4.20 -1.39 -3.60 -2.75 -3.04