Disseminated intravascular coagulation ppt

Disseminated intravascular coagulation (DIC) is a syndrome in which either the extrinsic or intrinsic or both pathways are activated to produce multiple fibrin clots in small blood vessels.

1. Disseminated intravascular coagulation Presented by: Shivangi Sharma

2. Introduction

3. Definition Disseminated intravascular coagulation (DIC) is a syndrome in which either the extrinsic or intrinsic or both pathways are activated to produce multiple fibrin clots in small blood vessels. The resultant reduction of the coagulation factors and platelets results in bleeding.

4. Coagulation process Lets understand through the whiteboard ..

5. obstetric complications amniotic fluid embolism eclampsia premature separation of placenta retained dead fetus

6. Malignancies acute promyelocytic leukemia adenocarcinoma

7. Infections septicemia septic abortion gram – ve sepsis

8. Miscellaneous snake bites severe burns anaphylaxis giant haemangioma

9. Secondary fibrinolysis following DIC, fibrinolysis gets activated and FDPs-D- Dimer formed has an inhibitory effect on clot formation. Plasmin formed inactivates FV, VII, IX and XI which further inhibit intrinsic coagulation cascade

10. Classification

11. Petechiae

12. Purpura

13. Investigations

14. Cont.. COMPLETE BLOOD COUNT PERIPHERAL BLOOD SMEAR PROTHROMBIN TIME FIBRINOGEN LEVEL MARKERS OF ENDOGENOUS THROMBIN GENERATION

15. Management BLOOD COMPONENT THERAPY - FRESH FROZEN PLASMA - PLATELETS - FRESH BLOOD

16. Cont.. ANTICOAGULANT THERAPY -Heparin and other anticoagulant therapy to inhibit thrombin.

17. Nursing management Assessment Nsg diagnosis Goal Nursing intervention Implementation Evaluation

18. Summary Lets summarize through a chart …

19. Bibliography Robbins & Cotran, “pathologic basis of disease” south asia edition , Elsevier publication, vol1, 663-665 Dr. Tejindar Singh, “Textbook of Hematology” , arya publication , 3rdedition , 228

20. Cont.. Brunner & Suddharth , “textbook of medical-surgical nursing” south asia edition , wolters kluwer publication , 13 th edition , vol2 565-568 www.slideshare.net