Disseminated Intravascular coagulation.pptx

This presentation discuss all the asects of disseminated intravascular condition.

1. Disseminated I ntravascular Coagulation Dr. Desh Deepak Assistant Professor, VMD, SVPUAT

2. Disseminated Intravascular Coagulation Synonyms: Consumption coagulopathy or defibrination syndrome Thrombo-haemmoragic syndrome caused by SIRS induced activation of coagulation cascade and characterised by depletion of clotting factors, paradoxical bleeding and (multiple organ dysfunction syndrome) MODS

3. Etiology Severe diseases and conditions that initiates SIRS viz septicemic diseases, toxemic diseases, metritis, mastitis, colitis, gastroenteritis, immune mediated diseases and severe traumatic injuries. Release of procoagulant material in blood in cancer and brain injuries.

4. Pathogenesis Two mechanisms responsible for DIC Excessive release of tissue factors/thromboplastin/factor III (severe trauma, surgeries, obstetric and sepsis) Widespread endothelial injuries

5. Pathogenesis

6. Pathogenesis

7. Clinical manifestations DIC produces two types of manifestations either bleeding or organ dysfunction. DIC is clinically presented in two major forms acute form which is fulminating DIC and chronic form with subclinical DIC without any bleeding symptoms Bleeding symptoms : Hematemesis, melena, pulmonary hemorrhages and excessive bleeding. Organ failure symptoms : Respiratory or renal insufficiency, hypotension and impaired cerebral blood flow

8. Diagnosis

9. Disseminated Intravascular Coagulation

10. Therapeutic management

11. Therapeutic management

12. Therapeutic management

13. Thank you

14. Image credit to Google, used for education purpose only