Diuretics drug on kidneyMOA.pptx drugs acting on

kidney

1. C ARBONIC A NHYDRASE I NHIBITORS

2. INDICATIONS Glaucoma [ ↓AH] Acute Mountain Sickness [ ↓CSF] To alkalinize urine in acidic dg poisoning UTI Metabolic acidosis [body fluid with acid] ADR Hypokalaemia metabolic acidosis [ The loss of base causes a metabolic acidosis] The ↑ delivery of Na to the collecting -- ↑ exchange of Na for K, with resulting hypokalaemia C ARBONIC A NHYDRASE I NHIBITORS

3. Liver Disease Hepatic coma --- ↓ excretion of NH3 in alkaline urine. COPD COPD-worsening of metabolic acidosis condition C ARBONIC A NHYDRASE I NHIBITORS-C/I

4. OSMOTIC DIURETICS

5. Mannitol USE ↓ ICT-Head injury and Cancer /tumour ↓IOP-M[iv], Gly [p/o], Iso- sorbide [p/o]-draw fluid from eye-to-blood --↓IOP] Maintain osmolality on ECF after dialysis Glaucoma Related Eye Surgery P’cologically-Inert Freely filtered at

6. ADR Expansion of ECF-Pulmonary Oedema HNV Glycerol-Hyperglycaemia water deficit and hypornatremia

7. C/I with CHF Pulmonary Oedema—Expand ECF

8. USE Acute Pulmonary Oedema Acute Renal failure Hypercalcaemia [ ↑ Ca OUT] Hyperkalaemia Barbiturate and Halide poison [Forced diuretics] ↑ sd ICP-- ↓ Blood Volume--↓ICP ADR Renal Action Hypokalaemia Depletion of Ca+ Hypovolemia Hypotension Hyper Uricemia [Gout case] Extra Renal Action Ototoxicity Pancreatitis Hypr -Sensitivity Myalgia GI-Upset Hepatic encephalopathy C/Is Anuria-lack of Urine Hypr - snty -compound Allergy to Sulpha Dgs

9. Transient Receptor Potential Vanilloid

10. USE Oedema Hypertension Ca++ Nephrolithiasis [ ↑Ca absorption] Diabetes Insipidus [ ↓ 50% Vol] Bromide Intoxication [Like Cl-] ADR Electrolyte disturbances DM-May suppress Insulin ↓ Uric acid secretion High Dose- Hypr Lipidaemia Hypr-snty ↓ Amonia secn - ↑Liver accln -Hepatic encephalopathy C/Is Supha dg with allergy

11. ADR CAIs Acidosis Hypokalaemia Drowsiness Fatigue Hypersensitivity Rxn PSD With ACEIs-Hyperkalaemia OD ↑ Blood Volume Pulmonary Oedema ↓ Osmolality Hyponatremia Xanthine Cramping-Stomach pain N.V.D.H ↑ Urination Loss of appetite

12. C/Is CAIs Hypersensitivity Low Na and K level Kidney or Liver disease Acidosis Adrenocortical Insufficiency Cirrhosis PSD Hyperkalaemia [Avoid K supplement-KD] OD Renal Disease Pulmonary Oedema Intracranial Bleeding Dehydration Heart Failure

13. ANTI DIURETICS

14. arginine vasopressin