What is membranous nephropathy (MN)? Membranous nephropathy (MN) is a condition that causes your immune system to attack glomeruli, the tiny filters in your kidney. Your kidneys have thousands of glomeruli. These filters clean waste products from your blood. If you have membranous nephropathy, your glomeruli become inflamed. MN can cause your kidneys to stop filtering waste as well as they should.MN can develop suddenly or slowly get worse over a long time. It’s common for people to have MN for several years and not know it. MN is a type of glomerular disease. Other terms for MN are membranous glomerulopathy or membranous glomerulonephritis.
Types of Membranous Nephropathy
Primary Membranous Nephropathy
Secondary Membranous Nephropathy
How common is membranous nephropathy?
Symptoms and causes
What’s the most common cause of membranous nephropathy (MN)?
What complications can happen if I have membranous nephropathy (MN)? Health issues and complications from membranous nephropathy can include:High cholesterol (higher than average levels of fat in your blood).High blood pressure.Severe swelling.Kidney disease.Kidney failure.Deep vein thrombosis (DVT).Pulmonary embolism (PE).
Diagnosis and Tests. How is membranous nephropathy (MN) diagnosed? If you have any symptoms of nephrotic syndrome (like protein in your pee, swelling or decreased kidney function), your primary care provider may refer you to a nephrologist. A nephrologist is a healthcare provider who specializes in diseases and conditions of the kidneys. Your nephrologist will use several tests to confirm an MN diagnosis. Tests. Blood test: Blood urea nitrogen (BUN), creatinine and albumin.Glomerular filtration rate (GFR): Studying a blood sample to see the speed at which your kidneys are filtering waste. Kidney biopsy. Taking a small sample of kidney tissue and sending it to a lab to see if it contains an antibody associated with MN.Urine test: Measuring levels of protein and blood in your urine.
Treatments. Treatment for MN depends on the type and your symptoms. The goal of treatment is to reduce your symptoms and stop the disease from getting worse. Angiotensin-converting enzyme (ACE) inhibitors: Drugs that manage high blood pressure, lower urine protein levels and help reduce inflammation in your kidneys. ARBs (angiotensin receptor blockers): Medication to treat high blood pressure and kidney disease. Diuretics: Medications that remove excess fluid from your body (by causing you to pee more) and lower blood pressure. Cholesterol-lowering medications (statins): Medication to reduce cholesterol levels. Corticosteroids: Medication to reduce inflammation and suppress your immune system (this helps it not attack your healthy cells). Blood thinners: Drugs that lower your risk for blood clots. Changes to your diet: Reducing salt intake and keeping your overall protein intake at a moderate level. Your healthcare provider will recommend what types of diet changes you should make.
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