Does palmitoylethanolamide(pea) have weight loss benefits

Palmitoylethanolamide(PEA) stimulates fat-burning receptor, to control appetite, and help weight loss.Palmitoylethanolamide supplement has been proved to have powerful anti-inflammatory and analgesic activity.It also influences many physiological functions that are related to cellular and metabolic homeostasis.

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DoesPalmitoylethanolamide(PEA)HaveWeightLossBenefits?
WhatisPalmitoylethanolamide(PEA)?

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Palmitoylethanolamide(PEA)alsocalledN-2hydroxyethylpalmitamideorpalmitoylethanolamineisachemicalthatbelongtoagroupof
fattyacidamides.Itisabiologicallyactive,naturallyoccuringlipidthatactsonCR2(cannabinoidreceptor)andinteractswithinflammatory
cellsinournervoussystem.Palmitoylethanolamidesupplementhasbeenprovedtohavepowerfulanti-inflammatoryandanalgesicactivity.
Italsoinfluencesmanyphysiologicalfunctionsthatarerelatedtocellularandmetabolichomeostasis.
WhatisPalmitoylethanolamide(PEA)MadeFrom?
Palmitoylethanolamide(PEA)(544-31-0)isnaturallyproducedinthebodywhenthebodyneedstocombatpainorinflammation.Several
plantsandanimalsalsoproducePEA.Thischemicalcanthereforebeextractedfrompeanuts,alfalfa,soylecithin,milk,soybeans,andegg
yolk.
HowDoesPalmitoylethanolamide(PEA)Work?
Palmitoylethanolamide(PEA)stimulatesPPARalphawhichisananti-inflammatory,energy-enhancing,andfat-burningreceptor.Through
stimulationofthisreceptor,Palmitoylethanolamideinhibitsthereleaseofseveralinflammatorysubstancesandactionofpro-inflammatory
genesthereforereducinginflammation.Thisalsotriggersregulationoflipidmetabolism.
PEAtriggersanumberofindirectreceptor-mediatedactivities.PEAindirectlystimulatescannabinoidreceptorsviadifferentindirect
mechanisms.PalmitoylethanolamideindirectlyactivatecannabinoidreceptorssuchasCB1andCB2byfunctioningasafalsesubstratefor
FAAH(fattyacidamidehydrolase),theenzymeusedintheendocannabinoidAEAdegradation,thereforeleadingtoalowereddegradation
ofAEA.

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ThisactioncausesincreasedAEAlevelsand,inturn,morestimulationofcannabinoidreceptor-mediatedsignaling.Also,recentresearch
hasshownthatPalmitoylethanolamideboostsCB2receptormRNAlevelsandproteinfollowingPPAR-αactivation.
PEAthereforelowerstheactivityofFAAHwhichbreaksdowncannabinoidanandamide.Thisboostscalminganandamidelevelsinyour
body,helpingyoutofeelrelaxedandfightpain.

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DoesPalmitoylethanolamide(PEA)HaveWeightLossBenefits?
Yes,PEAprovidesnumerousWeightlossbenefits.Wehavediscussedsomeofthebenefitsbelow.
i.Palmitoylethanolamide(PEA)preventsagainstpainandinflammationduringandafteraweightlossworkout
Obesitycausestheappearanceofaninflammatoryprocessthatmaybeinitiatedevenafteramoderateweightgain.
Palmitoylethanolamideactsasanendogenouslipidthathasshownnumerousanti-inflammatoryproperties.
Aresearchstudywascarriedouttoinvestigatetheanti-inflammatoryeffectofPalmitoylethanolamidesupplementonhumanadipocytes.
ThestudydemonstratedthatPEAinhibitstheLPSstimulatedsecretionofTNF-alphabyhumanadipocytes.Itwasalsoprovedthat
Palmitoylethanolamideshowedagreatanti-inflammatoryactivityasthechemicalcancompletelystopthehighincreaseinthelevelsof
TNF-alphaintheserumwhichhadbeentreatedwithahighdoseofLPS.
ScientistsfoundoutthatwhenPEAbindstoPPAR-α,thereceptorisstimulatedandthisenhancestheabilityofyourbodytoregulate
breakdownoffats,weightmanagement,anti-inflammatoryactivity,andpain-relievingresponses.Becauseofitslackoftoxicity,PEA
provedtobeveryefficientinthepreventionagainstobesity-associatedinsulinresistance.
Therefore,useofpalmitoylethanolamidepowdermaybehelpfultoactivebodybuilders,whoarelookingtoshedofffat,buildleanmuscle,
andpreventworkout-inducedinflammationthatwouldcausepainduringandafterheavyexercises.
ii.Palmitoylethanolamide(PEA)causesadecreaseinappetite

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Sciencesuggeststhatfattyacidethanolamideshasabigroleinthecontroloffeedingbehavior.Astudywascarriedouttoinvestigatethe
roleofpalmitoylethanolamide(oneoftheethanolamides)inweightgainandappetiteregulation.Ovariectomizedratsshowingincreased
weightgainweretreatedwithpalmitoylethanolamide(30mg/kgsc)forfiveweeks.Afterthis,bloodwascollected,andadiposetissueand
hypothalamuswereremovedforcellular,molecular,andhistologicalmeasurements.
Researchersshowedthatpalmitoylethanolamide(PEA)causedaremarkablereductioninfoodintake,fatmass,andbodyweight.
PalmitoylethanolamidealsotransformedadiposetissuemacrophagestoM2leanphenotype,associatedwithadecreaseofinflammatory
adipokines/cytokines.
MoreresearchonhumanbodyshowsthatactivationofPPAR-αbyPEAstimulatesthefeelingofsatisfactionandfullness.Maintenanceof
ahealthyweightlowerstheoccurrenceofinflammationandpainafterexercise.Ifyou’reanactivebodybuilder,experiencing
inflammationandpainduringorafteranexerciseduetoexcessbodyweight,thismaylowertheefficiencyofyourworkoutordiscourage
youfromworkingoutasoftenasyou’dotherwisewant.TakingPEAmayeliminatethisproblem.

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iii.Palmitoylethanolamide(PEA)Enhancesmetabolism
DuetotheabilityofPalmitoylethanolamide(PEA)tobindtoPPAR-α,itisabletoimprovemetabolism,promotefatburningandcausea
feelingofsatietyandfullness.

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Itisthereforeavaluabletoolinassistingactiveindividualsimprovetheirexercisesandreachtheirweightlossgoals.Thesimplestwayto
boostyourintakeofPEAisbytakingpalmitoylethanolamide(PEA)supplementonadailybasis.Thisisoneofthesafestnaturalwayto
assistyouachievethemostfitshapeeverandenableyoutohaveapain-freeandcomfortableworkout.
HowDoesPalmitoylethanolamide(PEA)HelpWithWeightControl?
WhenPEAbindstoPPAR-α,itstimulatesthebodytobreakdownmorefat,insteadofhavingitstored.Thisstimulationalsoenhancesthe
abilityofthebodytoburncholesterolwhichmayotherwisecausequickweightgain.Insimplerterms,Palmitoylethanolamidesupportsa
healthymetabolism,resultinginheightenedenergylevels.Thehighenergylevelsinturnassistsyoushedoffweightbyenablingyourbody
toburnmorecaloriesduringandafteranexercise.
Palmitoylethanolamide(PEA)OtherBenefits
Otherpalmitoylethanolamide(PEA)benefitsinclude:
i.Improvementofbrainhealth
TakingpalmitoylethanolamidepowdermayhelppatientswithstrokeandneurodegenerativediseasesbecausePEAassistsbraincells
surviveandreduceinflammation.Inastudyinvolving250strokepatients,PEAwasprovedtoprovideapositiveeffectonoverallbrain
health,cognitiveskills,anddailyfunctioning.

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ii.Healingcommoncold
Palmitoylethanolamide(PEA)benefitsinfightingcommoncoldwereprovedinastudythatinvolved900soldiers.APEAdosageof
1200mg/daywasseentolowerthedurationandthesymptomsofcoldsuchassorethroat,headaches,andfever.Infourotherstudies,
Palmitoylethanolamidereducedthechancesgettingacoldandtheseriousnessofthesymptoms.
iii.Relievingjointpain
PEAisessentialinrelievingarthritisbecauseitreducesthedevelopmentofchronicpainandlowersjointdestructionprogressassociated
witharthritis.InananimalstudythatinvestigatedPEAcombinedwithquercetinshowedthatthiscombinationloweredinflammatory
chemicallevelsinthejointfluid,enhancedjointfunction,reducedpainandprotectedcartilageagainstdamage.
Palmitoylethanolamide(PEA)Dosage
Consultyourhealthcareproviderbeforetakingpalmitoylethanolamide(PEA)powder.Moreclinicalresearchisexpectedregardingthe
medicaluseofPEAbuttheavailableinformationshowsthatPalmitoylethanolamide(PEA)supplementissafe.
Inclinicalstudiespalmitoylethanolamide(PEA)dosageof300mgto1.8g/daywasused.Inastudyinvolving610patientswhocouldn’t
effectivelycontroltheirchronicpainwithnormaltherapies,apalmitoylethanolamidedosageof600mgwasadministeredtwotimesper
dayforthreeweeks.Thiswasfollowedwithonedoseperdayforonemonthinadditiontoasingleanalgesictherapy.Theused
palmitoylethanolamide(PEA)dosagewasfoundtoreducethemeanscorepainintensityinallthepatientswhocompletedthe
observationalstudy.

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Palmitoylethanolamidehalflifehasbeenprovedtobeeighthours,buttheachievedpositiveeffectsarefeltthroughoutthedaybecause
thepalmitoylethanolamidesupplementclosesthesourceofpainandinflammationcompletely.
TherecommendeddosageofpalmitoylethanolamidePEAfornervepainis1.2g/day.
Therearenoknownpalmitoylethanolamidecontraindications,andpatientswithreducedliverandkidneyfunctioncanbetreatedwith
palmitoylethanolamidePEApowder,asitsmetabolismiscellular,localizedandindependentofliverandkidneyfunctions.Itdoesn’t
interferewithotherdrugtherapiesanditdoesn’ttriggerdrugtodruginteractions.
WhatAreTheSideEffectsofPalmitoylethanolamide(PEA)?
Palmitoylethanolamide(PEA)sideeffectsinclude:
1.UsersreportedtoexperienceafeelingofheavinessinthestomachshortlyafterthePEAtabletsweretaken.
2.AfewusersrarelyexperiencedmilddiarrheaandgastrointestinaldiscomfortafterthesublingualPalmitoylethanolamideformulation.
ThisisbelievedtobecausedbytheuseofsorbitolasasweetenerinPEAformulation.
BuyPalmitoylethanolamide(PEA)

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GoodnewsisthatyoucannowbuyPalmitoylethanolamide(PEA)(544-31-0)online.However,bewarnedthatyou’llneedtocarryoutdue
diligencesincemostsuppliersofthissupplementarenotlegit.TomakesurethatyouarebuyinglegitPEA,taketimetoresearchwidely
andfindoutwhatpreviousbuyersaresayingaboutthembyreadingtheirpalmitoylethanolamidereviews.
Youshouldonlybuythesupplementfromapopularmanufacturerwhohasagoodreputation.Suchamanufacturershouldhavemore
positivereviewsandhighratingsfrombuyersthannegativeones.

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Articleby:
Dr.Liang
Co-founder,thecompany’scoreadministrationleadership;PhDreceivedfromFudanUniversityinorganic
chemistry.Morethannineyearsofexperienceinorganicsynthesisfieldofmedicinalchemistry.Rich
experienceincombinatorialchemistry,medicinalchemistryandcustomsynthesisandprojectmanage
References:
NCBI-PubChem(25March2005).“CompoundSummary:Palmitoylethanolamide”.PubChem.NCBI.NLM.NIH.gov.Bethesda,MD:US
NLM-NationalCenterforBiotechnologyInformation(NCBI).Retrieved12thMarch2020.
LoVerme,J.;Fu,J.;Astarita,G.;LaRana,G.;Russo,R.;Calignano,A.;Piomelli,D.(2005).“Thenuclearreceptorperoxisome
proliferator-activatedreceptor-alphamediatestheanti-inflammatoryactionsofpalmitoylethanolamide”.MolecularPharmacology.67
(1):15–19.
Jonsson,K.O.;Vandevoorde,S.V.;Lambert,D.M.;Tiger,G.;Fowler,C.J.(2001).“Effectsofhomologuesandanaloguesof
palmitoylethanolamideupontheinactivationoftheendocannabinoidanandamide”.BritishJournalofPharmacology.133(8):
1263–1275.