Drug delivery system

DDs plays an important role in new pharmaceutical investigations.

1. Drug delivery systems: realistic or optimistic attitudes Seyedmohammad Motevalli Prof. Nie Spring 2016

2. Drug Delivery System DDS defined as a formulation or a device that enables the introduction of a therapeutic substance in the body and improves its efficacy and safety by controlling the rate, time and place of release of drugs in the body. Jain 2008

3. Cancer Cells Kreso and Dick 2014

4. The Tumor Microenvironment Thakor and Gambhir 2013

5. The primary goals for research of Nano-biotechnology in drug delivery include: More specific drug targeting and delivery Reduction in toxicity while maintaining therapeutic effects Greater safety and biocompatibility Faster development of new safe medicines

6. Passive DDS

7. Targeted drug delivery

8. Peer 2007 Rani 2014 Bae 2011 Philip 2010 Tiwari 2012 Kudgus 2014 Khan 2013

9. Patents and Articles publication www.Lexinnova.com

10. $$$$$$$ www.Lexinnova.com

11. Nanoparticles Evolution Zhang 2013

12. Examples of FDA approved DDS in the market

13. -Continued Zhang 2013

14. Examples of nanoparticles u sed in cancer t herapy and their current stage

15. -continued Thakor 2013

16. Nanoparticles Type

17. Drug molecules and Targeting ligands Cagdas 2014

18. Copolymers Bonacucina 2011 www.Wikipedia.org

19. Stimuli R esponses Nanoparticles Chen 2016

20. Endogenous responses Mura 2013 Plank 2009 Chen 2016

21. Exogenous responses Mura 2013 Meng 2016 Jacob 2014

22. Late 1970’s Current Era Future First Nanoscale drug delivery system was lipid vesicles. Nowadays, liposomes, cream, capsule, tablets, gel, aqueous solution, aerosols/spray are used as forms of delivery. Nano enabled technology will take the maximum share of the market making up nearly 90% of drug delivery market. Considered impossible to administer the pharmaceuticals suspensions by intravenous means, due to obvious risks of embolism. 15% of market uses nanoparticle for drug delivery systems. Safe, Effective and without side effects. No wastage and increased bioavailability are going to be the basis of future drug delivery. First paper was published in 1976; it focused on development of nanoparticle for vaccine purposes. More specific for treatment. More-energetic and more-targeted methods, in which medications ride passively on the circulating bloodstream, where they may or may not arrive at micro cracks in a high enough dosage to initiate healing.

23. References Bae, Y. H. and K. Park (2011). "Targeted drug delivery to tumors: myths, reality and possibility." Journal of Controlled Release 153(3): 198 . Bonacucina , G., et al. (2011). " Thermosensitive self-assembling block copolymers as drug delivery systems." Polymers 3(2): 779-811 . Çağdaş , M., et al. (2014). Liposomes as Potential Drug Carrier Systems for Drug Delivery, INTECH . Chen, Y.-C., et al. (2016). "Non-metallic nanomaterials in cancer theranostics : a review of silica-and carbon-based drug delivery systems." Science and Technology of Advanced Materials . Jain, K. K. (2008). "Drug delivery systems-an overview." Drug delivery systems : 1-50 . Khan, I. U., et al. (2013). "Microfluidics: a focus on improved cancer targeted drug delivery systems." Journal of Controlled Release 172(3): 1065-1074 . Kreso , A. and J. E. Dick (2014). "Evolution of the cancer stem cell model." Cell stem cell 14(3): 275-291 . Kudgus , R. A., et al. (2014). "Tuning pharmacokinetics and biodistribution of a targeted drug delivery system through incorporation of a passive targeting component." Scientific reports 4.

24. Meng , Z., et al. (2016). "NIR ‐ Laser ‐ Switched In Vivo Smart Nanocapsules for Synergic Photothermal and Chemotherapy of Tumors." Advanced Materials 28(2): 245-253 . Mura, S., et al. (2013). "Stimuli-responsive nanocarriers for drug delivery." Nature materials 12(11): 991-1003 . Peer, D., et al. (2007). " Nanocarriers as an emerging platform for cancer therapy." Nature nanotechnology 2(12): 751-760 . Philip, A. K. and B. Philip (2010). "Colon targeted drug delivery systems: a review on primary and novel approaches." Oman Med J 25(2): 79-87 . Plank, C. (2009). " Nanomedicine : silence the target." Nature nanotechnology 4(9): 544-545. Rani , K. and S. Paliwal (2014). "A review on targeted durg delivery: its entire focus on advanced therapeutics and diagnostics." Sch. J. App. Med. Sci 2(1C): 328-331 . Thakor , A. S. and S. S. Gambhir (2013). " Nanooncology : the future of cancer diagnosis and therapy." CA: a cancer journal for clinicians 63(6): 395-418 . Tiwari, G., et al. (2012). "Drug delivery systems: An updated review." International journal of pharmaceutical investigation 2(1): 2 . Zhang, Y., et al. (2013). "Advanced materials and processing for drug delivery: the past and the future." Advanced drug delivery reviews 65(1): 104-120. References

25. Thank you for your kindly attention