Dysplastic features of oral premalignant lesions and conditions.pptx

Dysplastoc Features

1. Dysplastic features Dr Uma Datar-Chougule

2. If you spot a leukoplakia / erythroplakia what should be your line of action??

3. biopsy

4. Why dysplastic features are important They are signs of premalignancy/malignancy. If potentially malignant lesion is diagnosed early, prognosis is better. Can be used to grade the dysplasia/carcinoma/sarcoma. Grade of the tumour/premalignancy is one of the deciding factors in treatment planning and prognosis of the patient.

5. Architectural Change Loss of stratification

6. Architectural changes Loss of Polarity of basal cells. D yskeratosis may be represented by individually keratinized cells or keratin pearls

7. Architectural changes Drop shaped rete ridges

8. Architectural Changes Atypical, increased and superficial mitosis

9. Abnormal and atypical mitosis

10. Architectural changes Loss of cohesion of cells

11. Nuclear Pleomorphism Cellular pleomorphism Anisonucleosis Anisocytosis Cellular changes

12. Cellular Change Increased Nucleocytoplasmic ratio Increased Number of size of nucleoli

13. Cellular Changes Hyperchromatism

14. Mild dysplasia

15. Moderate dysplasia

16. S evere dysplasia

17. Thank you!!!