Efficacy and Potency of drug

Pharmacology (Efficacy And Potency of drug)

1. Department of Pharmaceutical Department of Pharmaceutical
sciencessciences
33
rdrd
Semester Semester

2. Group membersGroup members

Mohammad AsadMohammad Asad

Hafiz JunaidHafiz Junaid

Amir Sohail KhanAmir Sohail Khan

Sana MushtaqSana Mushtaq

3. What is Pharmacodynamics
Drug response curve
EC50
Potency
Efficacy
Refrences

4. Pharmacodynacmics describes the
action of drug on body and influence
of drug concentration on magnitude
of response
Most of drugs exerts effect by
ineracting with receptor
An agent that can bind to recepor and
produces iological rsponse is called as
agonist

5. The interaction between drug and its
receptor can be described by a curve
called as drug response curve
on Vertical axix there is response of drug
On horizontal axix there is concentration
of dose

6. The magnitude of drug effect
depends on drug concentration at
receptor site and this availbilty and
concentration of drug at receptor is
determined by both dose of drug
administered and by drug
pharmacokinetics(ADME)

7. When no drug is added then no effect is
produced

8. When some drug is added then we get
response

9. By adding more drug we get maximum
response

10. A time will reach on which adding more
drug will not cause increase in response
because we have reached to maximum
effect

11. EC50EC50
Is concentration of drug needed to get half of the
maximum effect

12. Two important properties of drug can be found
by dose reponse curve
Efficacy
Potency
PotencyPotency
amount of drug necessary to produce
maximum effect is the potecncy of drug

13. Candesartan and ibesartan are
angiotensin receptor blocker
Candesartan is more potent then
Ibesartan because the dose range for
candesartan is 4 to 32 mg as compared to
dose range of ibesartan whose dose
range is 25 to 300 mg

15. Ability of a drug to elicit a response when it
interacts with a receptor
Efficacy is dependent on;
the number of drug-receptor complexes formed
efficiency of the coupling of receptor activation to cellular
responses.
Maximal efficacy of a drug assumes that all receptors
are occupied by the drug and if more drugs are
added, no additive response will be observed.
Maximal response (efficacy) is more important than
drug potency.
A drug with greater efficacy is more therapeutically
beneficial than the one that is more potent.

18. Lipincott pharmacology
Rang and dales pharmacology