Endometrial Histology: Normal findings, artefacts and metaplasia

This presentation of endometrial histology will be useful to medical students and Junior resident doctors starting postgraduate training in Histopathology

1. Endometrial Histology: Normal
findings, Artefacts and Metaplasia
A residentsteaching session
By
Dr.DaudaE. Suleiman (MBBS, MWACP, FMCPath)
Deptof Histopathology, ATBU/ATBUTH, Bauchi

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4. Types of endometrial samples
•Biopsy
–Pipelle, Suction, MVA
•Curretage
–D&C
•Hysterectomy
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5. Proliferative Phase Endometrium
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8. Proliferative endometrium
•Summary of features:
–Low Power
•‘blue’ appearance
•Round to tubular glands
•Regular, even spacing of the glands
–High Power
•Pseudostratified columnar cells
•Mitotic figures
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9. Secretory endometrium
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12. Secretory endometrium
•Summary of features:
–Low power
•‘pink’ appearance
•Irregularly shaped glands
•Can have crowding
–High power
•Single layer of cuboidal or columnar cells
•Predecidualized stroma
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13. Menstrual endometrium
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14. Menstrual endometrium
•Summary of features:
–Low power
•Stromal breakdown
–Condensed aggregates of stroma
–Admixed haemorrhage and inflammatory cells
–Higher power
•Variable glandular appearance
•Cannot assess glandular crowding
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15. Post-menopausal endometrium
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17. Post-menopausal atrophy
•Summary of features:
–Low power
•Scant; thin strips of epithelium
–Higher power
•Low columnar and cuboidal cells
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18. Artefacts in endometrial histology
•Telescoping
•Pseudo- crowding of glands
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19. Telescoping
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20. Artefactual crowding
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21. Metaplasia
•Squamous
–Non-morular
–Morular
•Tubal
•Eosinophilic (oxyntic)
•Mucinous
•Papillary syncytial
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22. Squamous non-morular metaplasia
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23. Squamous morular metaplasia
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24. Squamous metaplasia summary
•Non-morular
–Benign
–Associated with chronic irritation (infection, IUCD)
•Morular
–Rare in normal endometrium
–Associated with EIN and Endometrial ca
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29. Gestational changes: Arias-Stella
reaction
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30. Acknowledgement: Kyle Devins, MD
(@MD_Kyle)
THANK YOU!
QUESTIONS??
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