Ep 14 zuli shingala

herbal drugs and herbal remedies in prophylactic and dietary preventive therapy for COVID-19 in different way

1. PHYTOMEDICINES AS PROPHYLACTIC AND DIETARY THERAPY FOR COVID-19 PREVENTION Zuli Shingala M.Pharm (Pharmacognosy) GUIDE – Dr. Reshma Jain Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara EP-14 1

2. Introduction Currently our country has started vaccination to frontline corona worriers, but that doesn’t mean that now we don’t have to take precautions. Coronavirus is still out there. Since immune system of patients plays an essential role in COVID-19 infection, we can use food and herbs as dietary or complementary therapy to prevent the infection and strengthen immunity. Close contact between person to person increases the risk of transmission via droplets, such as from an infected person through coughing or sneezing or the interaction between health workers and patients with COVID-19. Aromatherapy has been used for thousands of years in Egypt and India to treat various diseases, and the antimicrobial and antiviral activity of essential oils have been confirmed by numerous studies . 2

3. Immunomodulatory herbs : 3 Ashwagandha improves the body's defense against disease by improving the cell-mediated immunity. It also possesses potent antioxidant properties that help protect against cellular damage caused by free radicals. Turmeric is a natural way to help bolster the immune system by increasing the immunomodulating capacity of the body. adding extra turmeric into diet during periods of stress or during flu season to help give immune system a little boost. The Tulsi drops not only works on  improving your immunity but even improve the rate of formation of new blood cells. You can take these drops to fight with various kinds of infections, fever, cold, sore throat, cough, flu and for detoxifying your body. Giloy acts wonderfully in chronic, recurrent fevers. It is an anti-inflammatory, antipyretic herb which helps to boost your immunity to fight against the infection and also helps in early recovery .

4. Activity of essential oils : Using essential oils vapors could increase their application against airborne bacteria and viruses. The anti-influenza virus activity of some essential oil vapors, such as that of Citrus bergamia (bergamot), Eucalyptus globulus (eucalyptus), Pelargonium graveolens (geranium), Cinnamomum zeylanicum leaf oil (cinnamon), and Cymbopogon flexuosus (lemongrass), has been reported. Their inhibitory mechanism is based on the inactivation of the principal external proteins of the influenza virus. The hemagglutinin protein of the virus appeared to be a major target of most of these oil vapors, and this may provide therapeutic benefits for people suffering from influenza or other respiratory viral infections. Aerosolized tea tree oil reportedly inhibits airborne viral particles of H11N9 subtype avian influenza virus. 4

5. Antiviral herbs : Surgical masks are good at preventing virus spread into the air and transmission to humans. However, after mask removal, the virus remains on the mask and is probably re-aerosolized, increasing the risk of human infection. Mask coating with an antiviral compound could be advantageous, but disinfectant toxicity to humans must be considered. Such anti-viral herbs are : Terminalia chebula against respiratory syncytial virus Curcumin against hepatitis A & B virus Quercetin against Dangue Virus Sambucus nigra agains influenza virus Gallic acid from Woodfordia fruticose against Enterovirus 71 Epigallocatechin from green tea against Enterovirus 71 Many restaurants use cleaning detergents for surface sanitization; however, their safety and disinfection efficiency need further consideration. Natural antiviral extracts from herbs could be added to cleaning detergents to increase their anti-SARS229 CoV-2 activity . 5

6. Conclusion Air sterilization without human health damage using essential oils could be a good way to prevent COVID-19. However, the minimum essential oil concentration needed for SARS-CoV-2 inhibition should be investigated. These studies provides obvious evidence supporting dietary therapy and herbal medicine as potential effective antivirals against SARS-CoV-2 and as preventive agents against COVID-19. Thus, dietary therapy and herbal medicine could be a complementary preventive therapy for COVID-19. However, these hypotheses require experimental validation in SARS-Cov-2 infection models and COVID-19 patients . 6

7. References Dietary therapy and herbal med Hudson, for COVID-19 prevention: A review and perspective, Suraphan Panyod, Chi-Tang Ho, Lee-Yan Sheen, Journal of Traditional and Complementary Medicine, June 2020. Antiviral Natural Products and Herbal Medicines, Liang-Tzung Lin Wen-Chan Hsu and Chun-Ching Lin, Journal of traditional and complementary medicine, May 2014, volume 4, issue 1, 24-35. COVID-19, prevention and treatment with herbal medicine in the herbal markets of Salé Prefecture, North-Western Morocco, Noureddine Chaachouay, European Journal of Integrative medicine, Jan 2021, issue 42 Current prevention of COVID-19 : natural products and herbal medicines, Junqing Huang, Gabriel Tao, Jingwen Liu, Frontiers in pharmacology, Oct 2020, volume 11. Anti-influenza virus activity of essential oils and vapors, Amrican journal of essential oils and natural products, Selvarani Vimalanathan, James Hudson, Aug 2014, Issue 2, 47-53 7