Obesity Case Study
10 mice were allocated in each group. Group 1 is the normal control, group 2 is the
high fat control, and group 3 is the test group fed with pioglitazone (30mg/kg).
Discussion: Obesity causes an increase in the production of free radicals, leading to
an increase in oxidative stress. Following obesity, a reduction in total antioxidant
capacity and the activity of enzyme such as catalase, adding up to other obesity
related problems (1,4,5). Pioglitazone activates PPAR п Ѓ§ type 1 and 2, improve
insulin sensitivity and glycemic control, in people with type 2 diabetes (8 9). In a
study by Bahramikia and colleagues , performed on rats, receiving a high fat diet, in
comparison with the control group, the levels of LDL C, total cholesterol, and... Show
more content on Helpwriting.net ...
The serum MDA level was increased in high fat control group, compared to the
normal control group , due to increase in fatty acids and decrease in serum
antioxidant capacity. Singh et al. reported that the use of pioglitazone (30 mg
/ kg), has reduced the serum MDA levels (19). Consistently, in the present study,
the serum MDA levels in the pioglitazone group was significantly decreased,
compared to the control group (p 0.05). In a study by Hussian and colleagues,
pioglitazone has reduced the serum glucose, LDL and cholesterol level in non
diabetic hyperlipidemia rats, compared to the controls (20). In the current study,
serum glucose, LDL and serum cholesterol levels were decreased in the third group,
compared to the second group (p 0.05). The UCP 1 gene expression alterations
observed in this study, can be due to the lipid alterations in the high fat diet groups
The UCP 1 gene expression alterations observed in this study, can be due to the high
fat consumption in these groups. Weight gain and decrease in TAC, the catalase
enzyme activity, and the antioxidants of the serum in the second group, compared to
the first group can be due to high calorie regimen and the free radicals produced by
the high fat diet, that has dominated the antioxidant capacity of the serum, which are
consistent with the data