Favorskii Rearrangement reactions

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1. Rearrangement reactions O ne atom or a group moves from one atom to another within same molecule Migration from a atom to adjacent atom is called 1,2-shift. Listen Carefully

2. Favorskii Rearrangement Rearrangement of cyclopropanones and α- halo ketones, which leads to formation of carboxylic acids, or carboxylic acid derivatives. RCH 2 C CH 2 Cl BASE RCH 2 CH 2 COO- O Listen Carefully

3. Hydroxide (OH) Carboxylic Acid (-COOH) Amine ( NH 2 ) Amide -CO NH 2 Alkoxide (-OR) Ester (-COOR) Listen Carefully

4. OH Base O Cl Cyclic α-halo ketones, the Favorskii rearrangement constitutes a ring contraction. 6-Membered 5-Membered Listen Carefully

5. Mechanism of Cyclic α -halo ketone- Listen Carefully

6. OH Base O Cl When there is a group on non-halogenated alpha position

7. When there is no α -Hydrogen then migration of the group will take place Listen Carefully

8. Mechanism Listen Carefully