FET BASED BIOSENSOR FOR NANOSCIENCE AND N

IT IS HELPFUL

1. FET BASED BIOSENSOR PRESENTED BY PREYADARSHINI R

2. BIOSENSOR The device is made up of a transducer and a biological element that may be an enzyme, an antibody or a nucleic acid. The bioelement interacts with the analyte being tested and the biological response is converted into an electrical signal by the transducer.

3. ELEMENTS OF BIOSENSOR

4. FET-BIOSENSOR Materials for the transducers are one of the most important components that need to be considered to fabricate FET biosensors. The two most popular nanomaterials attracting particular interests of scientists are silicon-based (silicon nanowire— SiNW ) and carbon-based (graphene and carbon nanotubes—CNTs) high selectivity and sensitivity real-time response label-free detection capabilities a)The illustration of a nanoscale FET biosensor with a cross-sectional view.

5. SiWFET -Biosensor b)Conductance based on p / n type. c) CgA (Chromogranin A) was released from neurons stimulated by glutamate and was detected by CgA -Ab/CNT-FET

6. FABRICATION Top down approach-lithographic processes combined with an electron-beam technique that defines SiNW -FETs by physically etching a single-crystalline silicon wafer. Bottom-up approach-chemical vapor deposition (CVD) reaction followed by SiNW assembly and electrode fabrication via the photolithographic or electronbeam lithographic procedure.

7. TOP-DOWN APPROACH BOTTOM-UP APPROACH

8. GRAPHENE FET BIOSENSOR Graphene-based FET sensors is based on the conductivity change in the sensing channel (graphene nanosheet) upon the binding of target biomolecules. ultra-thin thickness large specific surface area extremely high electron mobility high sensitivity to electronic perturbations from foreign molecules

9. FABRICATION

10. APPLICATIONS: Cardiovascular disease (CVDs) Cancer Diabetes AIDS\HIV DNA sequencing and DNA detection Genetic diagnosis Cell physiology research Detection of protein concentration

11. REFERENCES https://iopscience.iop.org/article/10.1149/2.0291807jss https://pdfs.semanticscholar.org/af2a/03caf120a1af4f84b9f424d3fda11af7a913.pdf https://www.sciencedirect.com/science/article/abs/pii/S1748013211000168 https://sci-hub.hkvisa.net/10.1557/jmr.2017.129 https://www.nature.com/articles/s41598-020-71591-w