FORMULATION COMPONENTS OF TDDS and its explaination.pptx

This presentation gives a brief on components required to formulate a tdds formulation

1. FORMULATION COMPONENTS OF TDDS

2. Basic Components Of TDDS Drug substance Polymer matrix Penetration Enhancers Adhesives Backing Laminates Release Linear Other Excipients

3. Drug substance For successfully developing a transdermal drug delivery system, the drug should have following property: Low molecular weight Affinity for both lipophilic and hydrophilic phase Low melting point Short half life and non irritating

4. Polymer Matrix Permeation Enhancer Role: Control the release rate of drug Examples of polymers: Natural: gelatin, cellulose derivatives, gums etc. Synthetic Elastomer: neoprene, silicone rubber etc. Synthetic Polymer : polyethylene, polyvinyl alcohol, polypropylene etc. Role: Substance that increase skin permeability, allowing the drug to pass through the stratum corneum. Examples: ethanol, dimethyl sulfoxide , oleic acid, glycols, essential oils, trepenes etc.

5. Adhesives Baking Laminates Purpose: Ensures the patch to adheres to the skin. Types of Adhesives: Acrylic, silicone-based, and polyisobutylene adhesives. Properties: non-irritating, maintain adherence over the application period , and allow controlled drug release. Role: Provides support and protection for the drug formulation and prevent external moisture or contaminants from affecting the patch. Materials: Polypropylene, polyester films.

6. Release Liner Role: protects the patch before use and is removed before application. Materials: silicone-coated paper or polyethylene-coated paper

7. Additional Excipients Plasticizers: Improve flexibility of the polymer matrix. Examples: dibutyl phthalate, triethyl citrate. Stabilizers: prevent degradation of the drug. Examples: antioxidants, UV absorbers.